Results 101 to 110 of about 568,676 (309)

Annual report 2002 - The Equality Authority

, 2003
Equality Authority ...
Equality Authority
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Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Annual report 2005 - The Equality Authority

, 2006
Equality Authority ...
Equality Authority
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Annual report 2003 - The Equality Authority

, 2004
Equality Authority ...
Equality Authority
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Tackling Health Inequalities in Cancer Screening: Experiences of Eastern European and African Communities in Northeast Scotland

Cancer Medicine
Introduction This report provides insights from ethnic minority community members who may be under‐served by the healthcare system in Northeast Scotland, focusing on how to improve the delivery of cancer screening programmes.
Sarah R. Prowse, Shaun Treweek, María José Pavez Larrea, Miriam Brazzelli, Adriana Uribe   +4 more
doaj   +1 more source

Annual report 2001 - The Equality Authority

, 2002
Equality Authority ...
Equality Authority
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The duty to promote race equality Race equality and public procurement : a guide for public authorities and contractors

, 2003
Spine title: Race equality and public procurementAvailable from British Library Document Supply Centre- DSC:m03/30426 / BLDSC - British Library Document Supply CentreSIGLEGBUnited ...
Great Britain. Commission for Racial Equality (United Kingdom)
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