Results 51 to 60 of about 2,102,601 (239)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Review of equality statistics [PDF]
, 2008 The Equality and Human Rights Commission (EHRC) commissioned this review as part of its remit to map the equalities landscape across England, Scotland and Wales.
Armstrong, J., Humphreys, L., Walby, S.
core +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
CIVIC LIFE: Evidence Base for the Triennial Review [PDF]
, 2010 This document forms part of the Equality and Human Rights Commission triennial review and covers equalities in civic life. It examines equality in political participation, freedom of language and freedom of worship.
Cutts, D +5 more
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Lessons Learned on Gender Equality [PDF]
, 2013 The purpose of this evaluation study is twofold: Firstly, to compile lessons learned from Danida evaluations, evaluation studies and other evaluation publications, and secondly, to distil a set of recommendations relevant to the roll-out of The Right to ...
Verner Kristiansen Aps
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Embedding race equality and internationalising the curriculum:Abertay University case study [PDF]
, 2018 As part of the HEA Scotland embedding equality and diversity in the curriculum (EEDC) strategic enhancement project, Abertay University focused on developing an infrastructure for the embedding of race equality and the internationalising of their ...
Cameron, Andrea
core
Quantum annealing with Jarzynski equality
, 2010 We show a practical application of the Jarzynski equality in quantum computation. Its implementation may open a way to solve combinatorial optimization problems, minimization of a real single-valued function, cost function, with many arguments.
A. K. Hartmann +2 more
core +1 more source