Results 101 to 110 of about 80,149 (308)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Evaluation on equality and efficiency of health resources allocation and health services utilization in China

open access: yesInternational Journal for Equity in Health, 2017
Background China is faced with a daunting challenge to equality and efficiency in health resources allocation and health services utilization in the context of rapid economic growth.
Jian Sun, Hongye Luo
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Measuring Gender inequality and equality in education [PDF]

open access: yes, 2015
Since 1995, considerable expertise has built up in measuring aspects of gender inequality and equality, and in researching these in education, particularly formal schooling.
Unterhalter, ES
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Equality of Opportunity and the Distribution of Long-Run Income in Sweden [PDF]

open access: yes
Equality of opportunity is an ethical goal with almost universal appeal. The interpretation taken here is that a society has achieved equality of opportunity if it is the case that what individuals accomplish, with respect to some desirable objective, is
Roemer, John E.   +2 more
core  

The Great Migration and Education

open access: yes, 2020
At the turn of the century, World War I created a demand for a labor work force. Labor recruiters looked to the South for a worker class desperate to escape the Jim Crow laws of the South.
Tonia Cansler-Meredith
core  

Gender equality culture : a survey to measure attitudes to gender equality

open access: yes, 2023
Könsfördelningen inom transportbranschen är fortfarande ojämn i Sverige. Att beräkna fördelningen av kön, löner och befattningar räcker inte för att ändra denna obalans; vi behöver studera attityder och normer, som kan kallas ”jämställdhetskultur ...
Stave, Christina   +2 more
core  

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