Results 131 to 140 of about 80,149 (308)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Overview of the extent of discrimination in Ireland

, 2013
Irish legislation prohibits discrimination in employment and service provision under nine grounds: age, disability, family status, gender, marital status, race/ethnic group/nationality, religious belief, sexual orientation, and membership of the ...
Vasquez del Aguila, Ernesto, Cantillon, Sara   +1 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Understanding Gender Inequality Actions in the Pacific: Ethnographic Case-studies and Policy Options Final report

, 2016
Gender equity is a key plank to European Commission activities and aid-funded initiatives and yet, despite many years of engagement achieving gender equity is many parts of the world remains a huge challenge.
Farran, Susan, Roell, Emilie, Crook, Tony, Farran, Sue   +3 more
core   +1 more source

Measurement of the power spectrum turnover scale from the cross-correlation between CMB lensing and Quaia

The Open Journal of Astrophysics
We use the projected clustering of quasars in the Gaia-unWISE quasar catalog, Quaia, and its cross-correlation with CMB lensing data from Planck, to measure the large-scale turnover of the matter power spectrum, associated with the size of the horizon at
David Alonso, Oleksandr Hetmantsev, Giulio Fabbian, Anze Slosar, Kate Storey-Fisher   +4 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Agreement for Sustaining Reconciliation Policies: facade measure or step forward on the road to reconciliation?; Labour law: a multitask reform and its impact on gender equality; Quotas: women’s representation on Company Boards of Directors and Boards of Auditors; The right to maternity leave for self-employed fathers examined by the Constitutional Court

, 2011
Agreement for Sustaining Reconciliation Policies: facade measure or step forward on the road to reconciliation?; Labour law: a multitask reform and its impact on gender equality; Quotas: women’s representation on Company Boards of Directors and Boards of
RENGA, Simonetta
core  

Education Policy and Equality of Opportunity

, 2008
We provide a measure of equality of educational opportunity in 54 countries, estimated as the effect of family background on student performance in two international TIMSS tests.
Gabriela Schütz, Ludger Wö�mann, Heinrich W. Ursprung, Ludger Wößmann   +3 more
core   +1 more source