Results 101 to 110 of about 6,523,161 (276)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Cheng Equation: A Revisit Through Symmetry Analysis
, 2019 The symmetry analysis of the Cheng Equation is performed. The Cheng Equation is reduced to a first-order equation of either Abel's Equations, the analytic solution of which is given in terms of special functions.
Halder, Amlan K +3 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Quantum Words and Newtonian Sentences, Structure of Language and Algebra [PDF]
Journal of Interdisciplinary Sciences, 2019 Language and algebra take their structure from two laws in physics; and algebra is a subset of language. 1) Through its property of discreteness, words take their structure from the quantum property of matter, where phonemes are digits, words are ...
William L. Abler
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
GRAPHO-ANALYTICAL STUDIES OF LINIAR EQUATION SYSTEMS
Journal of Industrial Design and Engineering Graphics, 2016 The paper presents the solving of linear three variables system using two methods: analytic and graphic methods. The solving of a such system implies four cases: compatible system with unique solution, simple-indeterminate compatible system, double ...
Marin Dumitru, Ligia Petrescu
doaj +2 more sources
Assessing A Hierarchy of Pre-Service Secondary Mathematics Teachers’ Algebraic Thinking
Asian Journal of Assessment in Teaching and Learning, 2011 The purpose of this study was to assess a hierarchy of Malaysian pre-service secondary mathematics teachers’ algebraic thinking in using equation. The content domains incorporated in this framework were linear pattern (pictorial), direct variation ...
Lim Hooi Lian Lian +2 more
doaj
Revista Brasileira de Terapia Intensiva, 2006 JUSTIFICATIVA E OBJETIVOS: Rever estratégias de avaliação da acidose metabólica dando ênfase ao método de Stewart-Fencl-Figge versus a abordagem tradicional de Henderson-Hasselbalch.
Manuela Borges Gavaza Barbosa +2 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source