Results 111 to 120 of about 4,215,064 (363)

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Cosmological consequences of a scalar field with oscillating equation of state. IV. Primordial nucleosynthesis and the deuterium problem [PDF]

, 2022
Shuxun Tian
openalex   +1 more source

On the equation of state of Dark Energy

, 2005
The formalism in order to obtain the Dark Energy equation of state is extended to non-flat universes and we consider the inequalities that must be satisfied by Phantom Dark Energy in this case.
Alam, André Ranquet, Bassett, Blanchet, Boisseau, Caldwell, Caldwell, Caldwell, Chevallier, Corasaniti, Dabrowski, David Polarski, Dicus, Espana-Bonet, Feng, Ferreira, Glazebrook, Gong, Holz, Hu, Huterer, Jain, Jarvis, Jassal, Johri, Knop, Knox, Kocsis, Lazkoz, Linder, Maor, Padmanabhan, Perlmutter, Perlmutter, Rapetti, Ratra, Riess, Riess, Roy Choudhury, Sahni, Sahni, Seljak, Shafieloo, Spergel, Tonry, Torres, Upadhye, Wetterich, Yeche   +48 more
core   +6 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

The Evolution of Parallel Electron Temperature in Magnetospheric Reconnection Inflows

Geophysical Research Letters
Using data from NASA's Magnetospheric Multiscale mission captured in a reconnection inflow on the magnetospheric side of Earth's dayside magnetopause, we find a region where the heat flux density gradient term balances the parallel compression term in ...
Daniel J. Gershman, Li‐Jen Chen, Ari Le, Jason Shuster, John C. Dorelli, Jonathan Ng, Barbara Giles, Adolfo F. Viñas, Roy Torbert, James L. Burch   +9 more
doaj   +1 more source

Nonparametric Reconstruction of the Dark Energy Equation of State

, 2010
A basic aim of ongoing and upcoming cosmological surveys is to unravel the mystery of dark energy. In the absence of a compelling theory to test, a natural approach is to better characterize the properties of dark energy in search of clues that can lead ...
A. Gelman, A. Shafieloo, A. A. Starobinsky, Bruno Sansó, C. E. Rasmussen, D. Gamerman, D. G. Bonfield, David Higdon, Herbert Lee, Katrin Heitmann, S. Banerjee, Salman Habib, Tracy Holsclaw, Ujjaini Alam   +13 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Rip Cosmology via Inhomogeneous Fluid

Galaxies, 2013
The conditions for the appearance of the Little Rip, Pseudo Rip and Quasi Rip universes in the terms of the parameters in the equation of state of some dark fluid are investigated. Several examples of the Rip cosmologies are investigated.
Alexander V. Timoshkin, Valerii V. Obukhov, Evgenii V. Savushkin   +2 more
doaj   +1 more source