Results 41 to 50 of about 4,888 (259)

Meloxicam ameliorates the systemic inflammatory response syndrome associated with experimentally induced endotoxemia in adult donkeys

Journal of Veterinary Internal Medicine, 2020
Background Little information is available about endotoxemia in donkeys. Characterizing the systemic inflammatory response (SIRS) to lipopolysaccharide (LPS) in donkeys would provide valuable clinical and therapeutic information. The effects of meloxicam
Francisco Javier Mendoza Garcia, Carlos Gonzalez‐De Cara, Raul Aguilera‐Aguilera, Antonio Buzon‐Cuevas, Alejandro Perez‐Ecija   +4 more
doaj   +1 more source

First glanders cases detected in Nepal underscore the need for surveillance and border controls

BMC Veterinary Research, 2022
Background Glanders is a transmissible zoonotic disease caused by Burkholderia mallei that infects equids and humans. No glanders cases in equids were reported so far in Nepal. Case presentation Following suspected glanders in animals with clinical signs
Koirala P, Maharjan M, Manandhar S, Pandey KR, Deshayes T, Wang G, Valvano MA, Laroucau K   +7 more
doaj   +1 more source

Diels‐Alder Click Chemistry as a Dynamic‐Covalent Crosslinking Method in Spheroid‐Encapsulating Hydrogels for Cartilage Engineering

Advanced Healthcare Materials, EarlyView.
This research shows the development of hydrogels with Diels‐Alder click chemistry for engineering cartilage‐like tissue. The hydrogels support cartilage spheroids which could be cultured for at least 28 days. Furthermore, the spheroids showed a tendency to fuse together into a more consistent construct, and produced important components needed for ...
Sanne M. van de Looij, Antonia G. Vasilopoulou, Lennard Spauwen, Antoinette van den Dikkenberg, Jasmijn V. Korpershoek, Mylene de Ruijter, Jos Malda, Bas G. P. van Ravensteijn, Tina Vermonden   +8 more
wiley   +1 more source

Frequency and factors associated of potential zoonotic pathogens (Borrelia spp., Rickettsia spp., Leishmania spp., and Anaplasma phagocytophilum) in equids in the state of Bahia, Brazil

Parasites & Vectors, 2021
Background Currently, various zoonotic diseases are classified as emerging or reemerging. Because equids have a direct relationship with various vectors, they are possibly more frequently exposed to zoonotic agents than are humans.
Sonia Carmen Lopo Costa, Jéssica de Souza Freitas, Fábio Santos Carvalho, Maria Julia Salim Pereira, Matheus Dias Cordeiro, Adivaldo Henrique da Fonseca, Márcia Mariza Gomes Jusi, Rosangela Zacarias Machado, Alexandre Dias Munhoz   +8 more
doaj   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Equine Hepacivirus: A Systematic Review and a Meta-Analysis of Serological and Biomolecular Prevalence and a Phylogenetic Update

Animals, 2022
Viral hepatitis has recently assumed relevance for equine veterinary medicine since a variety of new viruses have been discovered. Equine Hepacivirus (EqHV) is an RNA virus belonging to the Flaviviridae family that can cause subclinical hepatitis in ...
Giulia Pacchiarotti, Roberto Nardini, Maria Teresa Scicluna   +2 more
doaj   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Epidemiological survey of Neorickettsia risticii in equids from the State of Rio de Janeiro, Brazil

Pesquisa Veterinária Brasileira
: Equine neorickettsiosis (EN), also known as Potomac Horse Fever, is a non-contagious disease caused by the bacterium Neorickettsia risticii of the Anaplasmataceae family. The objectives of this study were to detect the presence of anti-N.
Erica C.R. Roier, Renata L. Costa, Marcus S. Pires, Joice A.R. Vilela, Tiago M. dos Santos, Huarrisson A. Santos, Cristiane D. Baldani, Carlos L. Massard   +7 more
doaj   +1 more source

Molecular Identification of Equine Herpesvirus 1, 2, and 5 in Equids with Signs of Respiratory Disease in Central Ethiopia

Veterinary Medicine: Research and Reports, 2021
Tuge Temesgen,1 Yitbarek Getachew,2 Haileleul Negussie2 1College of Agriculture and Natural Resource, Asossa University, Asossa, Ethiopia; 2Department of Clinical Medicine, College of Veterinary Medicine and Agriculture, Addis Ababa University, Bishoftu,
Temesgen T, Getachew Y, Negussie H
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