Results 21 to 30 of about 202 (168)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

(n,p), (n,2n), (n,d), and (n,α) cross-section calculations of 16O with 0-40 MeV energy neutrons

EPJ Web of Conferences, 2015
Oxygen is one of the elements which interacts with emitted neutrons after fission reactions. Oxygen exists abundantly both in nuclear fuel (UO2) and moderators (H2O).
Ozdemir Omer Faruk, Arasoglu Ali
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

27 Al, 54 Fe, 58 Ni ve 90 Zr Hedef Çekirdekleri İçin 10–30 MeV Enerji Aralığında (γ,p) Reaksiyon Tesir Kesiti Hesaplamaları

Süleyman Demirel Üniversitesi Fen-Edebiyat Fakültesi Fen Dergisi, 2014
Özet: Bu çalışmada; 27Al, 54Fe, 58Ni ve 90Zr gibi füzyon reaktörü yapı malzemeleri için 10–30 MeV enerji aralığında oluşturulan (γ,p) reaksiyonlarının denge ve denge–öncesi nükleer reaksiyon modelleri kullanılarak, proton üretim tesir kesitleri ...
Veli ÇAPALI, Hasan ÖZDOĞAN, S. Sedat DOĞAN, Abdullah KAPLAN   +3 more
doaj  

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Tiroid Sintigrafisinde Kullanılan 94,99,99m Tc ve 131I Radyonüklidlerinin Üretim Tesir Kesiti Hesaplamaları

Süleyman Demirel Üniversitesi Fen-Edebiyat Fakültesi Fen Dergisi, 2014
Özet: Bu çalışmada, tiroid kanser metastazlarının görüntülenmesinde ve tedavisinde kullanılan 94,99,99mTc ve 131I radyonüklidlerinin üretim tesir kesiti incelenmiştir. Hesaplamalar, 94Mo(p,n)94Tc 100Mo(p,2n)99Tc, 98Mo(d,n)99mTc, 99Ru(n,p)99mTc ve 131Xe(n,
Yıldız Ergün, Abdullah Kaplan
doaj  

Iwamoto-Harada coalescence/pickup model for cluster emission: state density approach including angular momentum variables

EPJ Web of Conferences, 2014
For low-energy nuclear reactions well above the resonance region, but still below the pion threshold, statistical pre-equilibrium models (e.g., the exciton and the hybrid ones) are a frequent tool for analysis of energy spectra and the cross sections of ...
Běták Emil
doaj   +1 more source