Results 51 to 60 of about 95,843 (262)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Süleyman Demirel Üniversitesi Fen-Edebiyat Fakültesi Fen Dergisi, 2014 Özet: Bu çalışmada; 27Al, 54Fe, 58Ni ve 90Zr gibi füzyon reaktörü yapı malzemeleri için 10–30 MeV enerji aralığında oluşturulan (γ,p) reaksiyonlarının denge ve denge–öncesi nükleer reaksiyon modelleri kullanılarak, proton üretim tesir kesitleri ...
Veli ÇAPALI +3 more
doaj
Study of pre-equilibrium contributions in proton spectra of 59Co(n,xp) reaction using TALYS-1.9 [PDF]
, 2022 In the present study we have calculated the proton spectra of 59Co(n,xp) using TALYS-1.9. TALYS uses all major reaction mechanisms like compound, pre-equilibrium and direct reactions.
Choudhary, Mahesh ; Department of Physics, Banaras Hindu University, Varanasi 221 005 India +4 more
core +2 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
He jishu, 2023 We reviewed the recent progress on strange particle production and hypernuclear physics both in experiments and in theories. The temporal evolutions of nucleons and resonances are described by the Skyrme energy density functional and relativistic ...
FENG Zhaoqing +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Süleyman Demirel Üniversitesi Fen-Edebiyat Fakültesi Fen Dergisi, 2014 Özet: Bu çalışmada, tiroid kanser metastazlarının görüntülenmesinde ve tedavisinde kullanılan 94,99,99mTc ve 131I radyonüklidlerinin üretim tesir kesiti incelenmiştir. Hesaplamalar, 94Mo(p,n)94Tc 100Mo(p,2n)99Tc, 98Mo(d,n)99mTc, 99Ru(n,p)99mTc ve 131Xe(n,
Yıldız Ergün, Abdullah Kaplan
doaj
EPJ Web of Conferences, 2014 For low-energy nuclear reactions well above the resonance region, but still below the pion threshold, statistical pre-equilibrium models (e.g., the exciton and the hybrid ones) are a frequent tool for analysis of energy spectra and the cross sections of ...
Běták Emil
doaj +1 more source
Performance parameters of explosives: Equilibrium and non-equilibrium reactions [PDF]
, 2022 S.136-141For the calculation of the performance parameters of combustion processes, equilibrium thermodynamic processes are taken into account. On the other hand, non-equilibrium reactions occur, mostly connected with low pressure burning. In this paper,
Volk, F., Barthelt, H.
core +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source