Results 61 to 70 of about 159,304 (309)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Competitive exclusion and coexistence of pathogens in a homosexually-transmitted disease model. [PDF]

PLoS ONE, 2011
A sexually-transmitted disease model for two strains of pathogen in a one-sex, heterogeneously-mixing population has been studied completely by Jiang and Chai in (J Math Biol 56:373-390, 2008).
Caichun Chai, Jifa Jiang
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

On the existence of a nontrivial equilibrium in relation to the basic reproductive number

International Journal of Applied Mathematics and Computer Science, 2017
Equilibrium analysis in autonomous evolutionary models is of central importance for developing long term treatments. This task typically includes checks on the existence and stability of some equilibria.
Wijaya Karunia Putra, Sutimin, Soewono Edy, Götz Thomas   +3 more
doaj   +1 more source

Andronov–Hopf and Bautin bifurcation in a tritrophic food chain model with Holling functional response types IV and II

Electronic Journal of Qualitative Theory of Differential Equations, 2018
The existence of an Andronov–Hopf and Bautin bifurcation of a given system of differential equations is shown. The system corresponds to a tritrophic food chain model with Holling functional responses type IV and II for the predator and superpredator ...
Gamaliel Blé, Víctor Castellanos, Iván Loreto-Hernández   +2 more
doaj   +1 more source

An existence theorem of a Pareto equilibrium

Applied Mathematics Letters, 1991
The author considers the following multicriteria game problem: Given are \(N\) players playing noncooperatively with their respective strategy sets \(X_ i\), \(i=1,\dots,N\). Minimize the payoff functions \((f^ i_ 1(x),\dots,f^ i_{k_ i}(x))\) of player \(i\) over the set of feasible outcomes \(x\in X\), where \(X=X_ 1\times X_ 2\times\dots\times X_ N\).
openaire   +2 more sources

Existence and Uniqueness of Equilibrium in a Reinsurance Syndicate [PDF]

SSRN Electronic Journal, 2008
In this paper we consider a reinsurance syndicate, assuming that Pareto optimal allocations exist. Under a continuity assumption on preferences, we show that a competitive equilibrium exists and is unique. Our conditions allow for risks that are not bounded, and we show that the most standard models satisfy our set of sufficient conditions, which are ...
openaire   +4 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Midpoint-width lexicographic equilibria: Existence results for interval-valued equilibrium problems

Results in Control and Optimization
This paper presents a new solution concept for interval-valued equilibrium problems using an appropriate interval ordering that considers both the central value and the uncertainty inherent in the data.
Somaye Jafari
doaj   +1 more source