Results 31 to 40 of about 370,819 (260)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
A Cost-Optimized Resource Provisioning Policy for Heterogeneous Cloud Environments
IEEE Access, 2017 To avoid the drawbacks of a pricing mechanism in heterogeneous cloud environments that considers only single resources, we propose a multi-resource combinatorial pricing mechanism in this paper.
Xin Chen +4 more
doaj +1 more source
Mathematics, 2022 Extreme multistability has frequently been reported in autonomous circuits involving memory-circuit elements, since these circuits possess line/plane equilibrium sets. However, this special phenomenon has rarely been discovered in non-autonomous circuits.
Bei Chen +4 more
doaj +1 more source
Mechanical Equilibrium of Biological Membranes
Biophysical Journal, 1972 The nature of mechanical and electrical forces on biological membranes in relation to mechanical equilibrium is examined. The presence of a double layer of electric charge is shown to give rise to an effective pressure drop across a curved membrane of finite thickness.
openaire +2 more sources
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
On the Concept of Equilibrium in Sanctions and Countersanctions in a Differential Game
Mathematics, 2023 This paper develops the methodology for modeling decision processes in complex controlled dynamic systems. The idea of balancing such systems (driving them to equilibrium) is implemented, and a new mechanism for the equilibria’s stability is proposed ...
Vladislav I. Zhukovskiy +1 more
doaj +1 more source