Results 51 to 60 of about 370,819 (260)

A novel global chemical reaction mechanism for large-scale hydrogen detonation simulation

Case Studies in Thermal Engineering
Conventional modeling strategies for large-scale detonation simulations suffer from a critical trade-off: detailed chemical mechanisms involve excessive computational costs, while typical single-step schemes lack sufficient predictive accuracy.
Xin Lin, Qing Zhang, Haoyang Liu, Lidong Cheng, Bin Zhang, Wei Zhong   +5 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Static Balancing of Robot Mechanisms and Manipulation Devices

Journal of Mechanical Engineering, 2018
The paper deals with static balancing of various kinds of mechanisms and manipulation devices using spring balancing mechanisms. In case of parallelogram robots and manipulation mechanisms a spring balancing mechanism exerting a constant force is used ...
Segla Stefan
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Kinematics Solving Method of a Tensegrity Parallel Mechanism Under Actuated

工程科学与技术, 2019
Tensegrity mechanisms are new type mechanism consist of a set of compressive components (rigid rods) and continuous tensile components (ties). The benefits of tensegrity mechanisms in comparison with conventional ones include low mass, small inertia ...
Wei ZHU, Hanbing LI, Chuanwei WANG, Kairong GU   +3 more
doaj  

Market Equilibrium Based on Cloud-edge Collaboration

CSEE Journal of Power and Energy Systems
Market participants can only bid with lagged information disclosure under the existing market mechanism, which can lead to information asymmetry and irrational market behavior, thus influencing market efficiency.
Tong Cheng, Haiwang Zhong, Qing Xia
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Dynamic fractional-order ISDR rumor propagation model incorporating refutation mechanism in complex networks

Scientific Reports
Rumor spreading has been posing a significant threat to maintain the normal social order. In this paper, we propose a ISDR rumor propagation model on scale-free networks that considers fractional-order and refutation mechanism.
Weiwei Zhu
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source