Results 51 to 60 of about 412,312 (307)

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

THE INERTIA FORCE EQUILIBRIUM ANALYSIS OF CRANK-GROUP DRIVING MECHANISM

Jixie qiangdu, 2017
Aiming at overcoming the deficiency of balance of the Crank-group Driving Mechanism,utilize Mass moment substitution method to translate the equilibrium problem of inertia force of Crank-group Driving Mechanism into the additional mass moment of branch ...
WU Yao, CAO JuJiang, YAN WeiLiang, XI WenJun   +3 more
doaj  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Static Balancing of Robot Mechanisms and Manipulation Devices

Journal of Mechanical Engineering, 2018
The paper deals with static balancing of various kinds of mechanisms and manipulation devices using spring balancing mechanisms. In case of parallelogram robots and manipulation mechanisms a spring balancing mechanism exerting a constant force is used ...
Segla Stefan
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

A novel global chemical reaction mechanism for large-scale hydrogen detonation simulation

Case Studies in Thermal Engineering
Conventional modeling strategies for large-scale detonation simulations suffer from a critical trade-off: detailed chemical mechanisms involve excessive computational costs, while typical single-step schemes lack sufficient predictive accuracy.
Xin Lin, Qing Zhang, Haoyang Liu, Lidong Cheng, Bin Zhang, Wei Zhong   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Kinematics Solving Method of a Tensegrity Parallel Mechanism Under Actuated

工程科学与技术, 2019
Tensegrity mechanisms are new type mechanism consist of a set of compressive components (rigid rods) and continuous tensile components (ties). The benefits of tensegrity mechanisms in comparison with conventional ones include low mass, small inertia ...
Wei ZHU, Hanbing LI, Chuanwei WANG, Kairong GU   +3 more
doaj  

Market Equilibrium Based on Cloud-edge Collaboration

CSEE Journal of Power and Energy Systems
Market participants can only bid with lagged information disclosure under the existing market mechanism, which can lead to information asymmetry and irrational market behavior, thus influencing market efficiency.
Tong Cheng, Haiwang Zhong, Qing Xia
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source