Results 71 to 80 of about 412,312 (307)

Mechanism analysis and chemical equilibrium modelling for liquid phase glycerol hydrogenolysis

open access: yesChemical Thermodynamics and Thermal Analysis
In this work, the chemical equilibrium of the glycerol (GLY) hydrogenolysis in the liquid phase was studied from the mechanism of the CO and CC bond cleavage and hydrogenation reactions using the commercial simulator UniSim Design ® in the range T ...
Martín N. Gatti   +3 more
doaj   +1 more source

Turbidity Currents With Equilibrium Basal Driving Layers: A Mechanism for Long Runout

open access: yesGeophysical Research Letters, 2018
Turbidity currents run out over 100 km in lakes and reservoirs, and over 1,000 km in the ocean. They do so without dissipating themselves via excess entrainment of ambient water. Existing layer‐averaged formulations cannot capture this.
R. Luchi   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

A Credit Mechanism for Selecting a Unique Competitive Equilibrium [PDF]

open access: yes
The enlargement of the general-equilibrium structure to allow default subject to penalties to appririate credit limits and default penalties results in a construction of a simple mechanism for a credit using society. We show that there generically exists
Cheng-Zhong Qin, Martin Shubik
core  

Physical mechanism for biopolymers to aggregate and maintain in non-equilibrium states

open access: yesScientific Reports, 2017
Many human or animal diseases are related to aggregation of proteins. A viable biological organism should maintain in non-equilibrium states. How protein aggregate and why biological organisms can maintain in non-equilibrium states are not well ...
Wen-Jong Ma, Chin-Kun Hu
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Technology Transfers and the Clean Development Mechanism in a North-South General Equilibrium Model [PDF]

open access: yes
This paper analyzes the potential welfare gains of introducing a technology transfer from Annex I to non-Annex I in order to mitigate greenhouse gas emissions.
Kenneth Backlund   +2 more
core  

Global stability of an SIS epidemic model with feedback mechanism on networks

open access: yesAdvances in Difference Equations, 2018
We study the global stability of endemic equilibrium of an SIS epidemic model with feedback mechanism on networks. The model was proposed by J. Zhang and J.
Xiaodan Wei, Gaochao Xu, Wenshu Zhou
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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