Results 81 to 90 of about 4,187,336 (304)
Turbidity Currents With Equilibrium Basal Driving Layers: A Mechanism for Long Runout
Geophysical Research Letters, 2018 Turbidity currents run out over 100 km in lakes and reservoirs, and over 1,000 km in the ocean. They do so without dissipating themselves via excess entrainment of ambient water. Existing layer‐averaged formulations cannot capture this.
R. Luchi +3 more
doaj +1 more source
Technology Transfers and the Clean Development Mechanism in a North-South General Equilibrium Model [PDF]
This paper analyzes the potential welfare gains of introducing a technology transfer from Annex I to non-Annex I in order to mitigate greenhouse gas emissions.
Kenneth Backlund +2 more
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Measuring the Stance of Monetary Policy in a Closed Economy: A Dynamic Stochastic General Equilibrium Approach [PDF]
This paper develops and estimates a dynamic stochastic general equilibrium model of a closed economy which provides a quantitative description of the monetary transmission mechanism, yields a mutually consistent set of indicators of inflationary pressure
Vitek, Francis
core
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Disrupting the Kinase–Phosphatase Equilibrium: A Unified Mechanism for Drug-Induced Eryptosis
Hematology ReportsThe advent of targeted cancer therapies has revolutionized oncology, yet the off-target effects of these agents on healthy cells remain a significant clinical challenge.
Mohamed Jemaà +5 more
doaj +1 more source
Physical mechanism for biopolymers to aggregate and maintain in non-equilibrium states
Scientific Reports, 2017 Many human or animal diseases are related to aggregation of proteins. A viable biological organism should maintain in non-equilibrium states. How protein aggregate and why biological organisms can maintain in non-equilibrium states are not well ...
Wen-Jong Ma, Chin-Kun Hu
doaj +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Implementability of Correlated and Communication Equilibrium Outcomes in Incomplete Information Games [PDF]
In a correlated equilibrium, the players’ choice of actions is affected by random, correlated messages that they receive from an outside source, or mechanism. This allows for more equilibrium outcomes than without such messages (pure-strategy equilibrium)
Igal Milchtaich
core
Molecular Oncology, EarlyView.Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi +2 more
wiley +1 more source