Results 71 to 80 of about 5,765,838 (310)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Nonlinear Inequality, Fixed Point and NashEquilibrium [PDF]

In this paper, we give new sufficient conditions for the existence of a solution of theg-maximum equality. As a consequence, we prove a new fixed point theorem.
Moussa Larbani, Rabia Nessah, Tarik Tazdaït   +2 more
core  

Asymptotical stability of a nonlinear non-differentiable dynamic system in microbial continuous cultures

Advances in Difference Equations, 2017
In this paper, we consider a nonlinear non-differentiable dynamic system in microbial continuous cultures involving all possible metabolic pathways of the inhibition mechanisms of 3-hydroxypropionaldehyde onto the cell growth and the transport systems of
Jiajia Lv, Liping Pang, Enmin Feng
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

On generalized equilibrium points

Journal of Mathematical Analysis and Applications, 2004
Let \(X=X_{1}\times X_{2}\times\cdots\times X_{n}\) be a product of Euclidean spaces and \(\varphi:X\times X\rightarrow\mathbb{R}\) be a function. This paper introduces the notion of \(\varepsilon\)-equilibrium point of \(f\), where \(\varepsilon=(\varepsilon_{1},\varepsilon_{2},\ldots\varepsilon_{n} )\in\mathbb{R}^{n}\), as follows: \(x=(x_{1},x_{2 ...
Kas, P, Kassay, G, Sensoy, ZB
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Each equilibrium point corresponds to the eigenvalue symbol judgment.

, 2023
Each equilibrium point corresponds to the eigenvalue symbol judgment.
Hui Su (53684), Shiming Wang (746738), Qiang Hou (495704)   +2 more
core   +1 more source

A Conservative Four-Dimensional Hyperchaotic Model with a Center Manifold and Infinitely Many Equilibria

Modelling
This paper presents a novel four-dimensional autonomous conservative model characterized by an infinite set of equilibrium points and an unusual algebraic structure in which all eigenvalues of the Jacobian matrix are zero.
Surma H. Ibrahim, Ali A. Shukur, Rizgar H. Salih   +2 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Solid-Liquid Equilibrium Study of Binary System Saturated Fatty Acid in Short Chain Alcohols [PDF]

Unsaturated fatty acids are potential to be used for preventing degenerative diseases and developing brain function in babies. Separation of unsaturated fatty acids from saturated fatty acids efficiently achieved by urea complexation fractionation method.
Plawi, Rudang Suryoadhi Suryatmoko, Majid, Difa Aulia, Setyawardhani, Dwi Ardiana   +2 more
core   +1 more source