Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Analysis on the dynamic evolution of the equilibrium point of "carbon emission penetration" for energy-intensive industries in China: based on a factor-driven perspective. [PDF]
Environ Sci Pollut Res Int, 2023 Liu J, Wei D.
europepmc +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Multiple time scales method for a two dimensional system with distributed delays
Annals of the West University of Timisoara: Mathematics and Computer ScienceBuilding on the simplified mathematical model derived from the dynamics of the hypothalamic-pituitary-adrenal (HPA) axis, which describes the interactions between ACTH and cortisol through a system of differential equations with distributed delays, this ...
Matei Maria Roxana
doaj +1 more source
A Short And Constructive Proof of Tarski's Fixed-Point Theorem [PDF]
I give short and constructive proofs of Tarski's fixed-point theorem, and of a much-used extension of Tarski's fixed-point theorem to set- valued maps.tarski, fixed-point theorem, supermodular, supermodular games, strategic complementarities, equilibrium
Federico Echenique
core
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source
Novel adaptive generalized principal component analysis algorithm based on Hebbian rule
Tongxin xuebao, 2020 In order to adaptively estimate the generalized principal component from input signals,a novel generalized principal component analysis algorithm was proposed based on the Hebbian linear neuron model.Since the autocorrelation matrices of the signals were
Yingbin GAO +3 more
doaj
Equilibrium points in n -person games [PDF]
Proceedings of the National Academy of Sciences, 1950 Soit un jeu à de \(n\) personnes, où chaque joueur possède un systeme fini de stratégies pures. Chacun d'entre eux ayant choisi une tactique de jeu, l'ensemble de ces tactiques constitute un \(n\)-uple de stratégies pures. A tout \(n\)-uple correspond un système défini de paiement entre les partenaires. L'A. considère chacun de ces \(n\)-uples comme un
openaire +3 more sources
Equilibrium plans in constrained environments [PDF]
In this paper we analyze equilibria in competitive environments under constraints across players'' strategies. This means that the action taken by one player limits the possible choices of the other players.
Vermeulen,Dries, Romero Morales,Dolores
core
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source