Results 61 to 70 of about 928,430 (295)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Mutation and selection in a large population [PDF]
, 2004 In this paper we study a large, but finite population, in which mutation and selection occur at a single genetic locus in a diploid organism. We provide theoretical results for the equilibrium allele frequencies, their variances and covariances and their
Cruikshank, A. +2 more
core +1 more source
Equilibrium selection in interdependent value auctions [PDF]
Mathematical Social Sciences, 2019 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Elnaz Bajoori, Dries Vermeulen
openaire +4 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Efficient Nash Equilibrium Under Adverse Selection [PDF]
SSRN Electronic Journal, 2011 This paper revisits the problem of adverse selection in the insurance market of Rothschild and Stiglitz. We propose a simple extension of the game-theoretic structure in Hellwig under which Nash-type strategic interaction between the informed customers and the uninformed fi rms results always in a particular separating equilibrium.
Theodoros M. Diasakos +1 more
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Evolutive equilibrium selection II: quantal response mechanisms [PDF]
, 2004 In this paper we develop a model of Evolutive Quantal Response (EQR) mechanisms, and contrast the outcomes with the Quantal Response Equilibria (QRE) as developed by McKelvey and Palfrey(1995).
Vaughan, R.
core
Fisher-Wright model with deterministic seed bank and selection
, 2016 Seed banks are a common characteristics to many plant species, which allow storage of genetic diversity in the soil as dormant seeds for various periods of time.
Koopmann, Bendix +3 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Priority Pricing for Efficient Resource Usage of Mobile Internet Access
Applied Sciences, 2021 Radio-frequency spectrum resources are finite and scarce, but their demand is increasing exponentially every year. Therefore, wireless network resources are too expensive to be wasted.
Sung-woo Cho
doaj +1 more source