Results 51 to 60 of about 381,577 (339)

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Clinical Course of Infection and Cross-Species Detection of Equine Parvovirus-Hepatitis [PDF]

, 2021
Birthe Reinecke, Mara Klöhn, Yannick Brüggemann, Volker Kinast, Daniel Tödt, Alexander Stang, Marcha Badenhorst, Katja N. Koeppel, Alan J. Guthrie, Ursula Groner, Christina Puff, Madeleine de le Roi, Wolfgang Baumgärtner, Jessika‐M. V. Cavalleri, Eike Steinmann   +14 more
openalex   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Hair follicle regional specificity in different parts of bay Mongolian horse by histology and transcriptional profiling

BMC Genomics, 2020
Background Different morphological structures of hairs having properties like defense and camouflage help animals survive in the wild environment.
Ruoyang Zhao, Wu Yihan, Yiping Zhao, Bei Li, Haige Han, Togtokh Mongke, Tugeqin Bao, Wenxing Wang, Manglai Dugarjaviin, Dongyi Bai   +9 more
doaj   +1 more source

Simultaneous analysis of 44 frequently abused corticosteroid drugs using polysaccharide‐based chiral column‐HRMS approach

Analytical Science Advances, 2021
Corticoids have found their way into the globe of sports, due to their anti‐inflammatory properties, and have often found to be added to dietary supplements for illegally improving the effectiveness of their products.
Abdul Khader Karakka Kal, Tajudheen K. Karatt, Jahfar Nalakath, Michael Benedict Subhahar, Shino Ann Koshy, Zubair Perwad, Muhammed Ajeebsanu M.P   +6 more
doaj   +1 more source

An alphaherpesvirus exploits antimicrobial beta-defensins to initiate respiratory tract infection [PDF]

, 2020
beta-Defensins protect the respiratory tract against the myriad of microbial pathogens entering the airways with each breath. However, this potentially hostile environment is known to serve as a portal of entry for herpesviruses.
Boyen, Filip, Daled, Simon, Dhaenens, Maarten, Laval, Kathlyn, Nauwynck, Hans, Pasmans, Frank, Poelaert, Katrien, Van Cleemput, Jolien, Vanderheijden, Nathalie   +8 more
core   +2 more sources

From Solution to Surface: How the Catalytic Environment Modulates Peptide Bond Cleavage by Metal‐Oxo Cluster Nanozymes

Advanced Science, EarlyView.
Comparison of homogeneous Hf12(sol) and heterogeneous Hf12(precip) metal‐oxo clusters enables investigation of how solubility influences nanozymatic reactivity and selectivity toward proteolysis, without introducing confounding factors from differences in cluster identity.
Kilian Declerck, Muhammed Jibin Parammal, Carlotta Seno, Thomas J. N. Hooper, Dimitrios Sakellariou, Jonathan De Roo, Nada D. Savić, Tatjana N. Parac‐Vogt   +7 more
wiley   +1 more source

Ten years of the horse reference genome: insights into equine biology, domestication and population dynamics in the post-genome era. [PDF]

, 2019
The horse reference genome from the Thoroughbred mare Twilight has been available for a decade and, together with advances in genomics technologies, has led to unparalleled developments in equine genomics.
Bellone, R, Finno, Carrie, Petersen, J, Raudsepp, T   +3 more
core   +2 more sources

Equine Sarcoids

Veterinary Clinics of North America: Equine Practice, 1998
Sarcoids, the most common tumor of the horse, are fibroblastic, wart-like skin lesions that show variable manifestations. They are often invasive and recurrent, although they do not fulfill all criteria of malignancy. Due to their anatomic location, these tumors can sometimes cause loss of use of the horse.
L, Goodrich, H, Gerber, E, Marti, D F, Antczak   +3 more
openaire   +2 more sources

Equine Influenza [PDF]

Cold Spring Harbor Perspectives in Medicine, 2020
Horses are the third major mammalian species, along with humans and swine, long known to be subject to acute upper respiratory disease from influenza A virus infection. The viruses responsible are subtype H7N7, which is believed extinct, and H3N8, which circulates worldwide.
openaire   +2 more sources