Results 41 to 50 of about 18,529 (246)

Direct Synthesis of High‐Valence Protein@UiO‐66 Composites: Linking Crystallization Pathways to Protein Encapsulation

Advanced Materials, EarlyView.
This work reports a direct, biocompatible method to synthesize UiO‐66, enabling one‐step encapsulation of proteins without compromising crystallinity or activity. Using advanced in situ and ex situ techniques, the study reveals that proteins integrate concurrently with MOF growth, forming crystalline protein@UiO‐66 nanoparticles, and provide insight ...
Jesús Cases Díaz, Jana Glatz, Elisa Merced Olivas, Ramon Pons, Joseph P. Patterson, Mónica Giménez‐Marqués   +5 more
wiley   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

A novel lytic phage infecting MDR Salmonella enterica and its application as effective food biocontrol

Frontiers in Microbiology
Salmonella enterica is a foodborne pathogen associated with both typhoid and non-typhoid illness in humans and animals. This problem is further exacerbated by the emergence of antibiotic-resistant strains of Salmonella enterica. Therefore, to meet public
Anu Bala Jaglan, Anu Bala Jaglan, Ravikant Verma, Medhavi Vashisth, Nitin Virmani, B. C. Bera, R. K. Vaid, Taruna Anand   +7 more
doaj   +1 more source

The Effects of Pre and Post Exercise Low-Level Laser Therapy on Biochemical Markers of Skeletal Muscle Fatigue in Equines [PDF]

, 2019
Our objective was to determine whether administering low-level laser therapy before or after exercise had the greatest effect on biochemical markers of skeletal muscle fatigue in equines such as cortisol and blood lactate.
Freeman, Carson
core   +2 more sources

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

Recombinant horse interleukin-4 and interleukin-10 induced a mixed inflammatory cytokine response in horse peripheral blood mononuclear cells [PDF]

Veterinary World, 2019
Background and Aim: Interleukin (IL)-4 and IL-10 activate plethora of immune cells and induce the humoral immune response. However, recombinant version of horse IL-4 and IL-10 has not been investigated to understand their immunomodulating activities ...
Sheetal Saini, Harisankar Singha, Priyanka Siwach, B. N. Tripathi   +3 more
doaj   +1 more source

Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

Virulence, 2023
Lumpy skin disease (LSD) was reported for the first time in India in 2019 and since then, it has become endemic. Since a homologous (LSD-virus based) vaccine was not available in the country, goatpox virus (GPV)-based heterologous vaccine was authorized ...
Naveen Kumar, Sanjay Barua, Ram Kumar, Nitin Khandelwal, Amit Kumar, Assim Verma, Lokender Singh, Bhagraj Godara, Yogesh Chander, Garvit Kumar, Thachamvally Riyesh, Deepak Kumar Sharma, Anubha Pathak, Sanjay Kumar, Ramesh Kumar Dedar, Vishal Mehta, Mitesh Gaur, Bhupendra Bhardwaj, Vithilesh Vyas, Sarjeet Chaudhary, Vijaypal Yadav, Adrish Bhati, Rakesh Kaul, Arif Bashir, Anjum Andrabi, Raja Wasim Yousuf, Abhimanyu Koul, Subhash Kachhawaha, Amol Gurav, Siddharth Gautam, Hari Audh Tiwari, Vijay Kumar Munjal, Madhurendu K. Gupta, Rajender Kumar, Baldev R. Gulati, Jyoti Misri, Ashok Kumar, Ashok Kumar Mohanty, Sukdeb Nandi, Karam Pal Singh, Yash Pal, Triveni Dutt, Bhupendra N. Tripathi   +42 more
doaj   +1 more source

Livestock trade networks for guiding animal health surveillance [PDF]

, 2015
BACKGROUND: Trade in live animals can contribute to the introduction of exotic diseases, the maintenance and spread endemic diseases. Annually millions of animals are moved across Europe for the purposes of breeding, fattening and slaughter.
A Bouma, A Carter, A Carter, A Nardo Di, B Häsler, Barbara Häsler, DJ Carolan, DJ Watts, DM Green, ESRI, European Commission, European Union, European Union, European Union, European Union, European Union Council Regulation (EC) 1/2005, European Union Council Regulation (EC) 623/2003, European Union Council Regulation (EC) 853/2004, European Union Council Regulation (EC) 854/2004, European Union. Council Regulation (EC) 722/2013, G Robins, H Roberts, J Frössling, J Storz, JJ McGlone, JM Read, Jo L Hardstaff, Jonathan R Rushton, JT Schnute, KL VanderWaal, KS Howe, LinkTAD, LJ Hoinville, M Bigras-Poulin, M Braks, M Ercsey-Ravasz, M Nöremark, M Werner, N Fegan, N Tadich, PLM Van Horne, PN Grigor, R Bivand, R Core Team: R, RP Smith, S Dee, S Rautureau, SS Chen, SW Ashworth, V Gewest   +49 more
core   +2 more sources

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

TGF-β inhibitor SB431542 suppresses SARS-CoV-2 replication through multistep inhibition

Journal of Virology
The coronavirus disease 2019 (COVID-19) pandemic highlighted the critical need for broad-spectrum antivirals with high resistance barriers. Here, we demonstrate that SB431542, a selective TGF-β receptor I (ALK5) inhibitor, exhibits potent antiviral ...
Assim Verma, Himanshu Kamboj, Garvit Kumar, Nitin Khandelwal, Benjamin E. Mayer, Jitender Rathee, Yogesh Chander, Alka Nokhwal, Shweta Dhanda, Ram Kumar, Ramesh Kumar Dedar, Sandeep Kumar Bejjanki, Deepti Parashar, Gayathri Pananghat, Bhupendra Nath Tripathi, Riyesh Thachamvally, Shalini Sharma, Naveen Kumar   +17 more
doaj   +1 more source