Results 231 to 240 of about 316,168 (290)

Preparedness for blackouts in Iberian Peninsula patients using home respiratory therapies. [PDF]

ERJ Open Res
Jiménez-Gómez M, Sayas-Catalán J, Hernando-Sanz A, Ribeiro C, Seabra B, Luján-Torné M.   +5 more
europepmc   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Perspective of Liberian surgical care providers on ethical issues in global surgical collaborations. [PDF]

PLoS One
Kruth M, Dieudonné L, Udwadia F, Binda C, Joos E, Joharifard S.   +5 more
europepmc   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Collaboration Between the Government and Healthcare Professional Organizations for the Implementation of Geriatric Emergency Departments in Taiwan. [PDF]

J Acute Med
Lee CH, Tan TH, Yang CJ, Ng CJ, Wu CY, Wu CC.   +5 more
europepmc   +1 more source

Medical Care Output and Productivity [PDF]

Daniel H. Ginsburg, Ina Kay Ford
core  

EEPD1 Inhibition Unleashes Antitumor Immunity in Colorectal Cancer by Activating the cGAS‐STING Pathway

Advanced Science, EarlyView.
In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo, Chong Wu, Xiaobo Li, Caina Ma, Jiamin Huang, Zishuo Chen, Weiling He, Tianyu Tao, Weijing Zhang   +8 more
wiley   +1 more source

Facilitators and barriers of general health service readiness in the primary level public health facilities of Baitadi, Nepal: A qualitative study. [PDF]

PLOS Glob Public Health
Bist A, Arjyal A, Subedi M.
europepmc   +1 more source

Marquette\u27s Medical Missionaries [PDF]

, 1966
Casey, Bessie
core   +1 more source

Breaking ground: insights from a WHO-approved surgical mission amid Sudan's healthcare collapse. [PDF]

Front Public Health
Irfan B, Ali S, Ardah R, Jaffery Z, Ahmed A, Othman N, Ali A, Ali SIQ, Burney M.   +8 more
europepmc   +1 more source