Results 41 to 50 of about 758,479 (312)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Community Eye Health Journal, 2010 In many low- and middle-income countries, it is often the people who are poor or with a disability - or both - who find it most challenging to access and pay for health care.
Mason I., Mathenge W.
doaj
Use of activPAL to Measure Physical Activity in Community-Dwelling Older Adults: A Systematic Review
Archives of Rehabilitation Research and Clinical Translation, 2022 Objective: To perform a systematic review of the literature to describe how the activPAL accelerometer has been used to measure physical activity (PA) in community-dwelling older adults to standardize collection of PA data in this population using this ...
Jennifer Blackwood, PhD +5 more
doaj +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
How to look after and care for a slit lamp
Community Eye Health Journal, 2010 The slit lamp is an essential and often used diagnostic instrument in ophthalmology. It provides illumination and magnification for the examination of many structures of the anterior segment.
Cordero I
doaj
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Equipment repaired is equipment gained
Community Eye Health Journal, 2009 According to WHO, at any one time, around 50 per cent of medical equipment in low- and middle-income countries cannot be used because of lack of maintenance or spare parts. We have found that unwillingness or inability to repair equipment and put it back
V Srinivasan
doaj
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Equipment maintenance and repair
Community Eye Health Journal, 2010 The repair and maintenance of ophthalmic equipment, including surgical instruments and diagnostic devices, can be compared to the maintenance of a motor vehicle, something many of us understand well.If you had a car, would you drive it until the fuel ...
Walia DS, Huria J, Cordero I.
doaj
Reduction of intra-hospital transport time using the easy tube arrange device [PDF]
Clinical and Experimental Emergency Medicine, 2016 Objective Critically ill patients sometimes require transport to another location. Longer intra-hospital transport time increases the risk of hemodynamic instability and associated complications.
Ki Hyuk Joo +9 more
doaj +1 more source