Results 71 to 80 of about 761,661 (289)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EFFICACY OF MODIFIED MULTICOMPONENT SYSTEM “1C: ENTERPRISE” IMPLEMENTATION

open access: yesПедиатрическая фармакология, 2016
Background: Automated accounting and controlling system “1C: Enterprise” is widely used in Russia for optimizing the system of controlling materials and technical resources. Medical organizations modify them in line with their primary activity objectives.
A. A. Modestov, S. A. Dukoyan
doaj   +1 more source

Aerospace electrode line [PDF]

open access: yes
A facility which produces electrodes for spacecraft power supplies is described. The electrode assembly procedures are discussed. A number of design features in the production process are reported including a batch operation mode and an independent ...
Miller, L.
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Mini-rack testbed evaluation [PDF]

open access: yes
The goal was to characterize the Health Maintenance Facility (HMF)-like mini-racks and drawers onboard the KC-135 as a test bed for the Space Station Freedom HMF racks. An additional goal was to evaluate the attachments, mounting points, and inner drawer
Gosbee, John   +2 more
core   +1 more source

The Protection System for the Superconducting Elements of the Large Hadron Collider at CERN [PDF]

open access: yes, 1999
The protection system for the superconducting elements of the Large Hadron Collider (LHC) [1] at the European Laboratory for Particle Physics (CERN), and its associated equipment are presented: quench detectors, cold diodes, quench heaters and related ...
Dahlerup-Petersen, K   +7 more
core  

Sharpening and tightening surgical scissors

open access: yesCommunity Eye Health Journal, 2011
How to test surgical scissors for sharpness, how to sharpen the scissors and how to tighten a loose joint.
Ismael Cordero
doaj  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

Home - About - Disclaimer - Privacy