Results 41 to 50 of about 573,638 (245)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Coarse and Fine Two-Stage Calibration Method for Enhancing the Accuracy of Inverse Finite Element Method

open access: yesSensors, 2023
The inverse finite element method (iFEM) is a novel method for reconstructing the full-field displacement of structures by discrete measurement strain. In practical engineering applications, the accuracy of iFEM is reduced due to the positional offset of
Jiewei Lu   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Deployment Dynamic Modeling and Driving Schemes for a Ring-Truss Deployable Antenna

open access: yesChinese Journal of Mechanical Engineering
Mesh reflector antennas are widely used in space tasks owing to their light weight, high surface accuracy, and large folding ratio. They are stowed during launch and then fully deployed in orbit to form a mesh reflector that transmits signals.
Baiyan He   +5 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Investigation on SMT Product Defect Recognition Based on Multi-Source and Multi-Dimensional Data Reconstruction

open access: yesMicromachines, 2022
The recognition of defects in the solder paste printing process significantly influences the surface-mounted technology (SMT) production quality. However, defect recognition via inspection by a machine has poor accuracy, resulting in a need for the ...
Jiantao Chang   +4 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Structural Optimization Design of Magnetoelectric Thin-Film Antenna for Bandwidth and Radiation Enhancement

open access: yesMicromachines
The acoustically actuated nanomechanical magnetoelectric (ME) antennas represent a promising new technology that can significantly reduce antenna size by 1–2 orders of magnitude compared to traditional antennas.
Xiangyang Li   +4 more
doaj   +1 more source

A High-Temperature and Frequency-Reconfigurable Multilayer Frequency Selective Surface Using Liquid Metal

open access: yesIEEE Access, 2022
A high-temperature and frequency-reconfigurable multilayer frequency selective surface (FSS) based on liquid metal is proposed in this work. After construction of a multilayer dielectric cavity with specific dielectric-shaped pillars and the injection of
Peng Li   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

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