Results 51 to 60 of about 2,352,578 (343)
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source
MicromachinesThe acoustically actuated nanomechanical magnetoelectric (ME) antennas represent a promising new technology that can significantly reduce antenna size by 1–2 orders of magnitude compared to traditional antennas.
Xiangyang Li +4 more
doaj +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Cotton spinning to climbing gear: practical aspects of design evolution in Lancashire and the North West of England [PDF]
, 2006 This article looks at the role of path dependency in the design of outdoor clothing and equipment, from the perspective of changing and overlapping industrial clusters in Lancashire and Sheffield, from the 1960s.
Love, T, Parsons, M C, Rose, M B
core
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Deployment Dynamic Modeling and Driving Schemes for a Ring-Truss Deployable Antenna
Chinese Journal of Mechanical EngineeringMesh reflector antennas are widely used in space tasks owing to their light weight, high surface accuracy, and large folding ratio. They are stowed during launch and then fully deployed in orbit to form a mesh reflector that transmits signals.
Baiyan He +5 more
doaj +1 more source
Research on the Error Averaging Effect in A Rolling Guide Pair
Chinese Journal of Mechanical Engineering, 2019 By studying the effects of geometric precision on kinematic accuracy, an error mapping model has been established, based on the hypothesis that a motion pair and its installation surface are rigid.
Yanbing Ni +3 more
doaj +1 more source
The effects of text direction of different text lengths on Chinese reading
Scientific Reports, 2023 This study investigates the effects of text direction (horizontal and vertical) and length (long and short) on Chinese reading performance. The experiment enrolled 68 university students aged 19–29 years who were asked to read articles.
Yanqun Huang +5 more
doaj +1 more source
Improved design of electrophoretic equipment for rapid sickle-cell-anemia screening [PDF]
, 1974 Effective mass screening may be accomplished by modifying existing electrophoretic equipment in conjunction with multisample applicator used with cellulose-acetate-matrix test paper.
Hirsch, I., Reddick, J. M.
core +1 more source