Results 41 to 50 of about 237,518 (267)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Fuzzy Inference System modeling to assess the potential risks in the medical equipment [PDF]
مدیریت صنعتی, 2017 Nowadays failure risk assessment of medical equipment considering the crucial role of proper functioning of these equipment, make it unavoidable necessity.
Mohammad Valipour khatir +1 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Acta Orthopaedica et Traumatologica Turcica, 2021 Bending of a Kuntscher nail which had been used in the treatment of a prior femoral diaphyseal fracture was encountered in a 37-year-old male patient who was admitted to hospital for a deformity in his left thigh caused in a car accident.
T. Caglar Kockesen +4 more
doaj
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Future Science OASpinal anesthesia is considered a safe and effective anesthetic technique. However, some complications may be encountered in clinical settings such as needle fracture or retention, which is a rare but serious complication.
Mustapha Nahle +5 more
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Model of Failure of Printing and Packaging Equipment at the Stage of Decommissioning
Технологія і техніка друкарства, 2018 The article considers the methodology of statistical modeling of reliability of printing and packaging equipment. Here is given the principal form of dependence of the reliability function on the time of operation of equipment with 4 periods.
Надежда Сергеевна Голуб
doaj +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source