Results 41 to 50 of about 1,156,921 (307)
The Twenty Year Effect - Avoiding Back To The Future Scenarios In Failure Analysis [PDF]
, 2004 The Materials Investigation Group at Bluescope Steel's Port Kembla Steelworks has carried out diagnosis of failure mechanisms for 40 years, with problems emerging with new equipment, and regrettably, from time to time, the same lessons having to be ...
Christian, Kerrie Anne
core
Cost-benefit modelling for reliability growth [PDF]
, 2003 Decisions during the reliability growth development process of engineering equipment involve trade-offs between cost and risk. However slight, there exists a chance an item of equipment will not function as planned during its specified life. Consequently
Hobbs GK +4 more
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
THE BENEFITS OF FMEA IN IMPROVING THE INDUSTRIAL PROCESS OF A CABIN AIR CARRIER [PDF]
Proceedings on Engineering SciencesThis paper aims to present improvement actions to reduce the failure risk of a new vehicle cabin air transporter developed in an automotive plant in the Sul Fluminense region by applying the Failure Modes and Effect Analysis (FMEA) tool.
José Salvador da Motta Reis +5 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Practical extensions to the level of repair analysis [PDF]
, 2010 The level of repair analysis (lora) gives answers to three questions that are posed when deciding on how to maintain capital goods: 1) which components to repair upon failure and which to discard, 2) at which locations in the repair network to perform ...
Basten, R.J.I. +2 more
core +3 more sources
Analysis of Deterioration in a Plasma Focus Device [PDF]
, 2018 Indexación: Scopus.The Plasma Focus (PF) is a kind of dense transient plasmas in with high-pulsed voltage. To produce devices for eld application it is necessary to obtain PF equipment able to operate for a long period of time.
Avaria, G. +9 more
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Towards a Simpler Selection Process for Maintenance Strategies [PDF]
, 2013 Recent research at four large manufacturing sites in the North East of England showed that maintenance organisations were failing because they were locked in a cycle of quick fix and mend despite deploying extensive planned maintenance policies ...
MacIntyre, John +2 more
core +1 more source