Results 51 to 60 of about 1,156,921 (307)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Аналіз надійності ремонтопридатного електрообладнання систем електропостачання бурових установок [PDF]
, 2007 Сформулированы задачи анализа надежности электрооборудования системы электроснабжения с учетом особенностей схем питания буровых установок. Приведен анализ ремонтопригодного електробурового оборудования.
Гладь, І. В. +2 more
core
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Frequency of PSV inspection optmization using statistical data analysis
Revista Produção Online, 2015 The present paper shows how qualitative analytical methodologies can be enhanced by statistical failure data analysis of process equipment in order to select an appropriate and cost-effective maintenance policy to reduce equipment life cycle cost.
Alexandre Guimarães Botelho
doaj +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10
FEBS Open Bio, EarlyView.Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee +6 more
wiley +1 more source
A method for intelligent fault diagnosis of coal mine safety monitoring system equipment
Meikuang AnquanIn view of the diversity of equipment failure causes in the field application of coal mine safety monitoring system at the present stage, for some deep-level equipment failure causes, field technicians do not have the ability to conduct in-depth analysis,
Weiguo ZHANG
doaj +1 more source
Chemical Engineering Transactions, 2013 In this paper, it is proposed to develop the fault diagnosis system using the principal component analysis (PCA) for the intelligent operation support system that calculates the effect of fault propagation in abnormalities situation and gives appropriate
Y. Munesawa, H. Minowa, K. Suzuki
doaj +1 more source
Ranking the economic importance of countries and industries [PDF]
, 2017 In the current era of worldwide market interdependencies, the global financial village has become increasingly vulnerable to systemic collapse.
Havlin, Shlomo +4 more
core +1 more source