Results 181 to 190 of about 256,327 (314)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Stimulus Equivalence: A Laboratory Artefact or the Heart of Language?

This thesis surveys some of the implications of the presented collection of publications, all of which address the phenomenon of stimulus equivalence.
Dickins, David
core  

Separability and aggregation of equivalence relations [PDF]

We provide axiomatic characterizations of two natural families of rules for aggregating equivalence relations: the family of join aggregators and the family of meet aggregators.
Debasis Mishra, Dinko Dimitrov, Thierry Marchant   +2 more
core  

Variability in anthracycline dose conversions and cardiotoxicity monitoring: insights from hospital pharmacists on institutional protocols in oncology practice. [PDF]

Support Care Cancer
Ditta SA, Jongbloed F, Manintveld OC, Brugma JD, Wlazlo N, Bos MEMM, van der Kuy HM, Mathijssen RHJ.   +7 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Hepatology e-consult responses generated by artificial intelligence demonstrate accuracy but require human oversight. [PDF]

Hepatol Commun
Huang HKT, Yen DW, Li MY, Jutras G, Deng LX, McCulloch CE, Pletcher MJ, Lai JC, Hameed B, Ge J.   +9 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

PHILOSOPHICAL TEXT AS A TRANSLATION OBJECT (BASED ON THE WORK OF S. A. KRIPKE “WITTGENSTEIN ON RULES AND PRIVATE LANGUAGE”)

Многоязычие в образовательном пространстве
The article examines the problems of informative translation, in particular, translating philosophical texts. The relevance of this research lies in the fact that philosophical texts are used not only by philosophers, but also by scientists of various ...
Yu.A. Borisenko, D.S. Vladimirov
doaj  

Adequate Sedation or Deep Sedation? Interpreting Sex-Neutral Dexmedetomidine ED50 Findings in Upper Limb Surgery [Letter]. [PDF]

Drug Des Devel Ther
Li Y, Li G, Zhang B.
europepmc   +1 more source