Results 201 to 210 of about 1,012,925 (234)

Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive decline is a disabling and variable feature of Parkinson disease (PD). While cholinergic system degeneration is linked to cognitive impairments in PD, most prior research reported cross‐sectional associations. We aimed to fill this gap by investigating whether baseline regional cerebral vesicular acetylcholine transporter ...
Taylor Brown, Giulia Carli, Prabesh Kanel, Stiven Roytman, Jaimie Barr, Nicolaas I. Bohnen, Roger L. Albin   +6 more
wiley   +1 more source

Evidence-Based Toxicology-Hypothesis Testing in Randomized Clinical Trials: Part III - Non-Inferiority. [PDF]

J Med Toxicol
Trebach J, Graebner A, Su MK.
europepmc   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Net Present Value Impact of FDA's Phase 3 Waivers on Monoclonal Antibody Biosimilar Development. [PDF]

Biologics
Ranbhor R, Kulkarni P.
europepmc   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli, Mudasir Andrabi, Tova Cohen, Pranali G. Patel, Tapasya Katta, Chen Lin   +5 more
wiley   +1 more source

Clinically validated deep learning auto-contouring for glioblastoma volumetric modulated arc therapy planning: a dosimetric equivalence study. [PDF]

Radiat Oncol J
Hamzaoui O, Oulhouq Y, Rezzoug M, Zerfaoui M, Bakkari D, Rrhioua A.   +5 more
europepmc   +1 more source

Temporary carbon dioxide removals to offset methane emissions. [PDF]

Nat Clim Chang
Venmans F, Rickels W, Groom B.
europepmc   +1 more source

A Defined-Area Bonding Approach for Microtensile Testing: A Reliable Alternative to Monoblock Sectioning for High-Hardness Restorative Materials. [PDF]

J Funct Biomater
Yamashita K, Kawamoto C, Toida Y, Kawano S, Hoshika S, Sano H, Tomokiyo A.   +6 more
europepmc   +1 more source

Therapeutic Equivalence of Eyluxvi (Aflibercept) to Eylea in Neovascular Age-Related Macular Degeneration: ALTERA Trial (Randomized). [PDF]

Ophthalmol Ther
Raczynska D, Ernest J, Baumane K, Sagong M, Akiyama K, Rauschning W, Vajas A, Nowosielska A, Dusova J, Majtánová N, Oleksy P, Kuneva I, Resch M, Lange N, Briede E, Bajdik B, Jeong A, Kozub B, Papp A.   +18 more
europepmc   +1 more source

Investigating the effects of TMS-related somatosensory inputs on TMS-evoked potentials provides evidence against significant interaction. [PDF]

Sci Rep
Gordon PC, Metsomaa J, Belardinelli P, Ziemann U.   +3 more
europepmc   +1 more source