Results 81 to 90 of about 129,523 (248)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Source language text, parallel text and model translated text: a pilot study in teaching translation
Forma y Función, 2007 The advance in cultural-oriented perspectives in Translation Studies has sometimes played down the text linguistic nature of translation. A pilot study in teaching translation was carried out to make students aware of the text linguistic character of ...
Bolaños Cuellar Sergio
doaj
Pedagogical responsiveness: Focus on the Ukuqonda institute’s mode of engagement in mathematics
Interdisciplinary Journal of Sociality StudiesThis paper was prompted by mathematics teachers’ challenges in implementing the proposed framework that centres on teaching for understanding, as opposed to teaching aimed at producing marks as evidence of achievement.
Satsope Maoto +2 more
doaj +1 more source
Evaluating the Equivalents of Popular Components of Mokhtarnameh Series [PDF]
پژوهشهای ترجمه در زبان و ادبیات عربیThe famous Mukhtarnameh series includes a lot of everyday language, such as idioms, ironies, assimilations, colloquial terms, slang, prayers, curses, and broken up prose, which helps the writers get their ideas across to the readers.
Ali Najafi Ivaki, Mohaddeseh Haddadi
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Russian Journal of Education and PsychologyBackground. During the study, it was noted the requirements for the professional competence of future translators and it was mentioned about the importance of the ability to model the translation process for a future specialist.
Vladislava A. Vikhlyaeva
doaj +1 more source
Facilitation of the equivalence--equivalence responding. [PDF]
Psicothema, 2011 Universidad de Oviedo. Facultad de Psicología; Plaza Feijoo, s. n.; 33003 Oviedo; Tel. +34985104146; Fax +34985104126;
Gómez Bujedo, Jesús +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source