Results 91 to 100 of about 4,496,022 (300)

First multi-institutional systematic comparison of the neutron ambient dose equivalent produced by proton therapy systems

Physics in Medicine & Biology
Abstract Objective. Isochronous cyclotrons, synchrocyclotrons, and synchrotrons are used to accelerate protons for proton therapy. An accurate measurement of neutron doses generated by these accelerators and associated delivery systems and its clinical relevance requires systematic protocols ...
Arash Darafsheh, Yao Hao, Anissa Bey, Michele M Kim, Eric S Diffenderfer, Lingshu Yin, Chin-Cheng Chen, Zhiyan Xiao, S Murty Goddu, Gabriele Zorloni, Paolo Grignani, Katia Parodi, Kelly Davidson, Tiezhi Zhang, Stephanie Perkins, Lee G Sobotka, Sina Mossahebi   +16 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Social models as dynamic theories: how to improve the impact of social and political sciences

Frontiers in Political Science
This paper explores the hypothesis that institutions are “dynamic social theories” that embody accumulated knowledge from everyday social experiments about how to do things in society.
Titus Alexander, Titus Alexander, Titus Alexander   +2 more
doaj   +1 more source

A Public Law Approach to Internet Standard Setting

Göttingen Journal of International Law, 2016
This article lays the foundations of a comprehensive analysis of the legitimacy of global Internet governance institutions from the perspective of public law.
Biel Company
doaj   +1 more source

The Critical Aspect on Fair Value Accounting And Its Implication To Islamic Financial Institutions.

, 2014
The Critical Aspect on Fair Value Accounting And Its Implication To Islamic Financial Institutions . Fair value accounting (FVA) paradigm replaced the historical cost accounting (HCA) in the development of accounting standards that FVA is more relevant ...
Jamaluddin Majid, Safri Haliding
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

COMMUNICATION OF ISLAMIC CIVIC ORGANIZATION IN OVERCOMING THE CONFLICT AND IMAGING AT NORTH SUMATERA (ANALYSIS OF MUHAMMADIYAH)

IJLRES (International Journal on Language Research and Education Studies), 2017
This study aims to show that organizational communication becomes very important in the life of the organization. The research results show that The nature of coordination is the realization of a cooperation, mutual respect or appreciation of duties ...
Hasnun Jauhari Ritonga, Stukur Kholil , Yusnadi   +2 more
doaj  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source