Results 31 to 40 of about 842,668 (260)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An Attack on a Non-Interactive Key Exchange from Code Equivalence

open access: yesTatra Mountains Mathematical Publications, 2022
Abstract A recent paper by Zhang and Zhang claims to construct the first code-based non-interactive key exchange protocol, using a modified version of the Code Equivalence Problem. In this paper we explain why this approach is flawed.
Persichetti, Edoardo   +2 more
openaire   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

International Comparison Results of Personal Dose Equivalent Hp(0.07) and Hp(3) in Beta Radiation

open access: yesYuanzineng kexue jishu
To establish the national primary standard for beta radiation tissue absorbed dose and to achieve international equivalence, the National Institute of Metrology (NIM) of China participated in the BIPM KCDB: EURAMET.RI(I)-S16 comparison that organized by ...
ZHANG Xuan1, 2, HUANG Jianwei1, LI Dehong1, , LIU Chuanfeng1, ZHANG Jian1, YANG Zhijun1, YANG Yang1
doaj   +1 more source

Employing Dynamic Symbolic Execution for Equivalent Mutant Detection

open access: yesIEEE Access, 2019
Equivalent mutants (EM) issue is a key challenge in mutation testing. Many methods were applied for detecting and reducing the equivalent mutants. These methods are classified into four classes: equivalent mutant detection, avoiding the generation of ...
Ahmed S. Ghiduk   +2 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Impact of water-related collective action on rural household welfare in the Upper Ewaso Ng’iro North Catchment Area: The application of the endogenous switching regression

open access: yesCogent Food & Agriculture, 2020
Key among government strategies to promote efficient and participatory water management in Kenya is through empowering local communities to manage water resources through Water Resource Users’ Associations (WRUAs) which is a collective action initiative.
Simon Ng’ang’a Mwaura   +5 more
doaj   +1 more source

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