Results 61 to 70 of about 36,128 (286)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Impact of the sea surface temperature forcing on hindcasts of Madden-Julian Oscillation events using the ECMWF model [PDF]

, 2012
This paper explores the sensitivity of hindcasts of the Madden Julian Oscillation (MJO) to the use of different sea surface temperture (SST) products as lower boundary conditions in the European Centre for Medium-range Weather Forecasts (ECMWF ...
E. de Boisséson, F. Vitart, K. Mogensen, M. A. Balmaseda   +3 more
core   +1 more source

An inter-comparison of Arctic synoptic scale storms between four global reanalysis datasets [PDF]

, 2020
The Arctic is becoming more accessible as sea ice extent continues to decline, resulting in higher human exposure to Arctic storms. This study compares Arctic storm characteristics between the ECMWF-Interim Reanalysis, 55-year Japanese Reanalysis, NASA ...
Day, Jonathan J., Hodges, Kevin I., Shaffrey, Len C., Vessey, Alexander, F.   +3 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The double peak in upwelling and heating in the tropical lower stratosphere [PDF]

, 2016
The processes responsible for double-peak latitudinal structures in the time-averaged tropical lower-stratospheric upwelling, centered near 70 hPa and 20°N/S, previously noted in ERA-Interim and other reanalysis and model datasets, are considered.
Haynes, P, Hitchcock, P, Ming, A
core   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Return levels of temperature extremes in southern Pakistan [PDF]

, 2017
Southern Pakistan (Sindh) is one of the hottest regions in the world and is highly vulnerable to temperature extremes. In order to improve rural and urban planning, it is useful to gather information about the recurrence of temperature extremes.
M. C. Bramati, M. Zahid, R. Blender, V. Lucarini, V. Lucarini   +4 more
core   +2 more sources

Dynamical Downscaling of ERA-Interim Temperature and Precipitation for Alaska

Journal of Applied Meteorology and Climatology, 2016
AbstractThe European Centre for Medium-Range Weather Forecasts interim reanalysis (ERA-Interim) has been downscaled using a regional model covering Alaska at 20-km spatial and hourly temporal resolution for 1979–2013. Stakeholders can utilize these enhanced-resolution data to investigate climate- and weather-related phenomena in Alaska. Temperature and
Peter A. Bieniek, Uma S. Bhatt, John E. Walsh, T. Scott Rupp, Jing Zhang, Jeremy R. Krieger, Rick Lader   +6 more
openaire   +1 more source