Results 61 to 70 of about 1,116,432 (297)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

ERA-interim reanalysis debiased at FLUXNET sites

, 2014
(preliminary) Exchanges of carbon, water and energy between the land surface and the atmosphere are monitored by eddy covariance technique at the ecosystem level.
Vuichard, N., Nicolas Vuichard (8010191), D. Papale, N. Vuichard, Papale, D., Vuichard, Nicolas, Papale, Dario, Dario Papale (8010194)   +7 more
core   +1 more source

New method for detecting extratropical cyclones: the eight-section slope detecting method

Atmospheric and Oceanic Science Letters, 2020
An algorithm for identifying extratropical cyclones (ECs) on the basis of gridded data is proposed in this study. The algorithm, which is named the eight-section slope detecting (ESSD) method, has five key procedures to identify an EC by using the mean ...
Lizhi JIANG, Shenming FU, Jianhua SUN
doaj   +1 more source

Irrigation Patterns Resemble ERA‐Interim Reanalysis Soil Moisture Additions

Geophysical Research Letters, 2017
AbstractIrrigation modulates the water cycle by making water available for plants, increasing transpiration and atmospheric humidity, while decreasing temperatures due to the energy that is needed for evaporation. Irrigation is usually not included in atmospheric reanalysis systems, but moisture can be added to the soil due to data assimilation.
O. A. Tuinenburg, J. P. R. de Vries
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Global Climatologies of Eulerian and Lagrangian Flow Features based on ERA-Interim

Bulletin of the American Meteorological Society, 2017
Abstract This paper introduces a newly compiled set of feature-based climatologies identified from ERA-Interim (1979–2014). Two categories of flow features are considered: (i) Eulerian climatologies of jet streams, tropopause folds, surface fronts, cyclones and anticyclones, blocks, and potential vorticity streamers and cutoffs and (ii ...
Sprenger, Michael, Fragkoulidis, Georgios, Binder, Hanin, Croci-Maspoli, Mischa, Graf, Pascal, Grams, Christian M., Knippertz, Peter, Madonna, Erica, Schemm, Sebastian, Škerlak, Bojan, Wernli, Heini   +10 more
openaire   +3 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Regional Hydrological Cycle over the Red Sea in ERA-Interim [PDF]

Journal of Hydrometeorology, 2016
Abstract The major sources of atmospheric moisture over the Red Sea are analyzed using ERA-Interim for the 1979–2013 period. The vertical structure of moisture transports across the coastlines has been computed separately for the western and eastern coasts of the Red Sea.
Zolina, Olga, Dufour, Ambroise, Gulev, Sergey K., Stenchikov, Georgiy L.   +3 more
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source