Results 71 to 80 of about 1,717,234 (288)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Global IWV trends and variability in atmospheric reanalyses and GPS observations [PDF]
Atmospheric Chemistry and Physics, 2018 This study investigates the means, variability, and trends in integrated water vapour (IWV) from two modern reanalyses (ERA-Interim and MERRA-2) from 1980 to 2016 and ground-based GPS data from 1995 to 2010. It is found that the mean distributions and
A. C. Parracho +3 more
doaj +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Evaluating Global Reanalysis Datasets as Input for Hydrological Modelling in the Sudano-Sahel Region
Hydrology, 2017 This paper investigates the potential of using global reanalysis datasets as input for hydrological modelling in the data-scarce Sudano-Sahel region. To achieve this, we used two global atmospheric reanalyses (Climate Forecasting System Reanalysis and ...
Elias Nkiaka, N. R. Nawaz, Jon C. Lovett
doaj +1 more source
Interim Beach Study Committee Transcript, March 26, 1970, Corpus Christi
, 1970 101 pagesTranscript of the Interim Beach Study Committee held on March 26, 1970, in Corpus ...
Interim Beach Study Committee
core
Verification of the new ECMWF ERA-Interim reanalysis over France
, 2010 . An evaluation of the global ECMWF atmospheric reanalysis ERA-Interim (with a 0.5° grid) is performed over France, based on the high resolution (8 km) SAFRAN atmospheric reanalysis.
C. Szczypta +7 more
core +1 more source
FEBS Open Bio, EarlyView.The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong +3 more
wiley +1 more source
Reduced ERA‐I Forecasting Skill During Forbush Decreases
Geophysical Research LettersCorrelations between week‐long cosmic ray flux perturbations and terrestrial cloud cover have previously been identified. Still, uncertainty persists on whether the cloud response is due to a physical link involving cosmic rays or caused by random ...
Jacob Svensmark
doaj +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source