Results 71 to 80 of about 1,116,432 (297)

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Evaluation of ERA‐Interim reanalysis precipitation products using England and Wales observations [PDF]

Quarterly Journal of the Royal Meteorological Society, 2014
Precipitation forecast data from the ERA‐Interim reanalysis (33 years) are evaluated using the daily England and Wales Precipitation (EWP) observations obtained from a rain‐gauge network. Observed and reanalysis daily precipitation data are both described well by Weibull distributions with indistinguishable shapes but different scale parameters, such ...
de Leeuw, J., Methven, J., Blackburn, M.
openaire   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evaluation of Remote Sensing and Reanalysis Snow Depth Datasets over the Northern Hemisphere during 1980–2016

Remote Sensing, 2020
Snow cover is a key parameter of the climate system and its significant seasonal and annual variability have significant impacts on the surface energy balance and global water circulation.
Lin Xiao, Tao Che, Liyun Dai
doaj   +1 more source

Arctic clouds and surface radiation – a critical comparison of satellite retrievals and the ERA-interim reanalysis [PDF]

Atmospheric Chemistry and Physics, 2011
Abstract. Clouds regulate Earth's radiation budget, both by reflecting part of the incoming sunlight leading to cooling and by absorbing and emitting infrared radiation which tends to have a warming effect. Globally averaged, at the top of the atmosphere the cloud radiative effect is to cool the climate, while at the Arctic surface, clouds are thought ...
Zygmuntowska, Marta, Mauritsen, Thorsten, Quaas, Johannes, Kaleschke, Lars   +3 more
openaire   +5 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Resolution, physics and atmosphere–ocean interaction – How do they influence climate model representation of Euro-Atlantic atmospheric blocking?

Tellus: Series A, Dynamic Meteorology and Oceanography, 2017
Atmospheric blocking events are known to locally explain a large part of climate variability. However, despite their relevance, many current climate models still struggle to represent the observed blocking statistics.
Kerstin Hartung, Gunilla Svensson, Erik Kjellström   +2 more
doaj   +1 more source

Notes on the correlation between sudden stratospheric warmings and solar activity [PDF]

Annales Geophysicae, 2019
A correlation between solar activity and normalized occurrence rate of sudden stratospheric warmings (SSWs) has been found. As a proxy for solar activity, the 10.7 cm solar radio flux has been used.
E. Vorobeva
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source