Results 61 to 70 of about 36,611,446 (304)

Conectivismo, ¿un nuevo paradigma del aprendizaje?

Desafíos, 2021
Este artículo expone y argumenta la teoría del aprendizaje llamada conectivismo; un nuevo paradigma del aprendizaje que se está empezando a aplicar en esta era digital, basado en la interconexión de los nodos de una amplia red de información y ...
Edgardo Cristiam Iván López De La Cruz, Frank Edmundo Escobedo Bailón   +1 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

O FIM DO CONSUMISMO: uma reflexão sobre o consumo compartilhado na era digital

Informação em Pauta, 2017
No decorrer dos anos, novas tecnologias de comunicação de massa foram criadas e passaram a usufruir de grande destaque, mudando até mesmo a forma de interação social e possibilitando algo; como o retorno de práticas como a do consumo colaborativo, desta ...
José Wellithon Batista Zacarias, Isabel Cristina Gonçalves Santos Batista, José Adailson de Albuquerque Pereira   +2 more
doaj   +1 more source

Serious invasions of privacy in the digital era: final report [PDF]

, 2014
This report provides the legal design of a tort to deal with serious invasions of privacy in the digital era, and makes sixteen other recommendations that would strengthen people’s privacy in the digital environment.

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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The digital era

The Annals of The Royal College of Surgeons of England, 2015
A very warm welcome to the New Year. With the start of 2015 has come a change in the Editorial Board. I am extremely proud to have been given the opportunity to take on the role of Editor-in-Chief of the Annals of the Royal College of Surgeons of England, a role that was originally bestowed upon Sir Cecil Wakeley in 1947.
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Trend Pemahaman Dan Praktik Komunikasi Politik Indonesia Di Era Digital

Tujuan penelitian ini ialah untuk melihat trend pemahaman dan praktik komunikasi politik indonesia di era digital. Penelitian ini menggunakan metode studi kepustakaan.
Putera, Roni Ekha, Yusril, Rahma Betri
core   +1 more source

Era digital: novos desafios para a prática do serviço social nas organizações não-governamentais [PDF]

, 2006
TCC (graduação) - Universidade Federal de Santa Catarina, Centro Sócio Econômico, Curso de Serviço Social.No presente trabalho propõe-se enfocar a questão da Revolução Tecnológica e da Exclusão Digital no Brasil, que tem como causas principais a ...
Bezerra, Andreza Inez
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