Results 141 to 150 of about 176,625 (261)

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

Comparable tolerability, symptom worsening, and treatment completion rates among different Helicobacter pylori eradication regimens in children. [PDF]

BMC Infect Dis
Gürcan Kaya N, Selbuz S.
europepmc   +1 more source

<i>Lactobacillus</i> supplementation for <i>Helicobacter pylori</i> eradication in children: A language-inclusive systematic review and meta-analysis of efficacy and safety. [PDF]

World J Clin Pediatr
Dargenio VN, Ricciardi S, Begucci M, La Grasta G, Maggi N, Dargenio C, Castellaneta SP, Cristofori F, Francavilla R.   +8 more
europepmc   +1 more source

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

Evidence-based clinical practice guidelines for peptic ulcer disease 2026. [PDF]

J Gastroenterol
Sugimoto M, Kamada T, Ito M, Iwamoto J, Okimoto T, Ono S, Kanno T, Chiba T, Tokunaga K, Nomura S, Murao T, Watanabe T, Asaoka D, Iwata E, Wang T, Ono H, Katsumata R, Kikuchi S, Konishi N, Sato S, Sunago A, Sekiguchi H, Cho H, Chinda D, Dohi O, Nakata A, Higashimori A, Hirashita Y, Misawa K, Mizukami K, Miyamori D, Mukohyama J, Mori H, Yoshida S, Watanabe J, Satoh K, Mizokami Y, Takagi A, Takeyama Y, Eguchi S, Watanabe S, Isomoto H, Itoi T, Mochida S.   +43 more
europepmc   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Adjunctive Synbiotic Therapy for <i>Helicobacter pylori</i> Eradication: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]

Life (Basel)
Romyasamit C, Duangchan T, Leepromma Y, Saki M, Sornsenee P.   +4 more
europepmc   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

From screening to surveillance: integrated prevention of <i>Helicobacter pylori</i>-associated gastric cancer in the Asia-Pacific region. [PDF]

Lancet Reg Health West Pac
Yoon J, Oh DY.
europepmc   +1 more source