Results 171 to 180 of about 103,567 (262)
Advanced Science, EarlyView.Herein, an ultrasound‐responsive BiO2‐X/siFn1 nanoplatform is developed to overcome anti‐PD‐1 resistance in hepatocellular carcinoma. Upon ultrasound irradiation, the platform downregulates fibronectin expression, while its sonothermal effect softens the dense extracellular matrix and activates antitumor immunity in the tumor microenvironment, thereby ...
Huimin Tian +10 more
wiley +1 more source
Dual pKa Lipid Nanoparticles for Lung‐tropic mRNA Delivery and pH‐Programmed Endosomal Escape
Advanced Science, EarlyView.Lipid nanoparticles’ bottleneck lies in low endosomal escape efficiency and liver‐dominant delivery after intravenous administration. To overcome these limitations, we present a stepwise pH‐programmed lipid nanoparticle system enabled by our newly synthesized ionizable lipid.
Seong Gi Lim +12 more
wiley +1 more source
WHO has established a two year period of zero cases as the prime criteria for certification of smallpox eradication. At the end of the two years (November 1977) an International Commission will come to Bangladesh.
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Unsung heroes of polio eradication [PDF]
As long as polio exists anywhere, it is a threat to children everywhere.Facts about the polio vaccineIn 1955, the polio vaccine is licensed for use, and the first vaccination campaigns begin.In 1988, polio cases worldwide 125 countries = 350,000 ...
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Potential of Nanoparticle‐Based Phototherapies for Future Treatment of Uveal Melanoma
Advanced Science, EarlyView.This review evaluates nanoparticle‐based phototherapies for uveal melanoma, highlighting emerging strategies to enhance tumor targeting, light delivery, and treatment precision. Preclinical data indicate improved efficacy and reduced toxicity, supporting their potential to enhance localized treatment and future translational advances. (Generated by the
Emilie Lambert +8 more
wiley +1 more source
Global Polio Eradication progress 1999 [PDF]
The global initiative to eradicate polio by the end of 2000 has become the largest public health initiative in history, and is spearheaded by WHO, Rotary International, U.S. Centers for Disease Control and Prevention, and UNICEF.
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Advanced Science, EarlyView.Leveraging the critical role of glutathione (GSH) in mediating drug resistance and scavenging reactive oxygen species (ROS) in cancer cells, a carrier‐free GSH‐consuming theranostic nanoprodrug, consisting of a BODIPY photosensitizer and the chemotherapeutic drug paclitaxel linked through a GSH‐consuming drug linker, is developed to deeply explore the ...
Hansheng Huang, Binglin Sui
wiley +1 more source
Entomological handbook for Aedes aegypti eradication [PDF]
"Eradication of an insect from a large geographical area is a most difficult entomological accomplishment. Moderately effective measures often suffice to reduce insect populations to an inoffensive level, but eradication requires a sharpening and ...
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Advanced Science, EarlyView.Water‐soluble amine‐functionalized polyhedral oligomeric silsesquioxane promotes concurrent latex coalescence and crosslinking, allowing epoxy‐functional particles to form continuous films without added volatile coalescing agents. The resulting multiscale‐reinforced waterborne coatings combine high strength, toughness, optical transparency, scratch ...
Chao Wang +7 more
wiley +1 more source
The Aedes aegypti Eradication Program [PDF]
Introduction -- History -- -- How the program works -- Organization -- Field operations -- Working with the community -- -- The program thus far -- Special problems -- Research.Two years ago the Public Health Service began a program to eradicate Aedes ...
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