Results 201 to 210 of about 488,696 (302)

Comparative virology and pathology of Monkeypox virus in Syrian hamsters, C57BL/6, and BALB/c mice: A framework for preclinical model selection

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This study compared monkeypox virus (MPXV) infection in three small animal models: Syrian hamsters, C57BL/6 mice, and BALB/c mice. Following intraperitoneal inoculation, Syrian hamsters exhibited the highest susceptibility, with rapid systemic viral dissemination, elevated splenic and renal viral burdens, and severe histopathological damage, followed ...
Xiaohui Wei   +9 more
wiley   +1 more source

Engineering Nanoemulsions to Maximize NIR‐II Fluorescence and Preserve Photothermal Performance of a Novel Boron Difluoride Formazanate Dye

open access: yesAngewandte Chemie, EarlyView.
An oil‐in‐water nanoemulsion transforms a boron difluoride formazanate (BDF) dye into a dual‐modal imaging‐guided theranostic agent (BDF‐NE). Its nonpolar oil core maximizes NIR‐II fluorescence while maintaining strong photoacoustic contrast to guide photothermal therapy with high photostability and 66.8% photothermal conversion efficiency, achieving ...
Nahyun Kwon   +14 more
wiley   +2 more sources

Establishment of a chronic aspiration pneumonia mouse model using oropharyngeal aspiration of food suspension

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Four aspiration methods (UV, IN, IT, and OA) were compared, and OA was identified as the most effective delivery technique. A chronic aspiration pneumonia model was then established through repeated OA of food suspension or gastric contents. Integrated analyses, including micro‐CT, histopathology, cytokine profiling, and RNA sequencing, revealed ...
Qianwen Li   +4 more
wiley   +1 more source

Synthetic O‐Polysaccharide Backbone Units for a Single Antigen Vaccine Against Two Major Non‐Typhoidal Salmonella Serovars

open access: yesAngewandte Chemie, EarlyView.
A modular strategy was developed to synthesize tri‐, hexa‐, and nona‐saccharides representing repeating units of the conserved O‐polysaccharide backbone of Salmonella. Conjugates of these glycans to bacteriophage Qβ induced strong IgG responses in mice and rabbits. Antibodies elicited recognized native O‐polysaccharides and conferred protection against
Xingling Pan   +7 more
wiley   +2 more sources

Prevention of Gastric Cancer. [PDF]

open access: yesMedicina (Kaunas)
Bățagă SM   +4 more
europepmc   +1 more source

Selenium Nanomaterials for Wound Healing: Synergistic Strategies from Anti‐Infection to Tissue Regeneration

open access: yesAdvanced NanoBiomed Research, EarlyView.
Selenium nanoparticles (SeNPs) are emerging as multifunctional platforms for wound healing, integrating antimicrobial, anti‐inflammatory, and proregenerative activities. This review summarises key mechanisms and recent advances in SeNP‐enabled composite dressings, immunomodulatory nanocomposites, microenvironment‐responsive hydrogels, photothermal and ...
Yangxia Chen   +10 more
wiley   +1 more source

2‐Azaazulenium Hemicyanine Dyes for NIR‐II Multimodal Imaging and Combined Phototherapy

open access: yesAngewandte Chemie, EarlyView.
A strategically engineered class of 2‐azaazulenium hemicyanines is developed, featuring bright fluorescence in the second near‐infrared (NIR‐II) window and multifunctional performance. SWJT‐OCH3 shows type I/II reactive oxygen species (ROS) generation and excellent photothermal activity.
Min Peng   +8 more
wiley   +2 more sources

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