Results 61 to 70 of about 453,075 (352)

Present Status of Malaria in Nepal

Journal of Nepal Medical Association, 2003
NA
G M Sakya
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Visualization of the Evolution and Transmission of Circulating Vaccine-Derived Poliovirus (cVDPV) Outbreaks in the African Region

Bio-Protocol
Since the creation of the Global Polio Eradication Initiative (GPEI) in 1988, significant progress has been made toward attaining a poliovirus-free world. This has resulted in the eradication of wild poliovirus (WPV) serotypes two (WPV2) and three (WPV3)
D. Owuor, Brook Tesfaye, Arthur Wakem, Sakma Kabore, Caroline Ikeonu, Mariette Doussoh, Priscilla Sigala, Idris Ibrahim, Abdullateef Jimoh, Idah Ndumba, Jermaine Khumalo, David Oviaesu, Cheroigin Kipchirchir, Carolyne Gathenji, John Kipterer, Kebba Touray, Hamisu Abdullahi, Kathleen Rankin, Ousmane Diop, Julius Chia, Ndoutabe Modjirom, Jamal Ahmed, Anfumbom Kfutwah   +22 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Epidemiology and genetic characterization of orphan polioviruses in Africa, 2022–2024: Unmasking silent transmission and implications for eradication

Vaccine: X
Background: The continued detection of orphan polioviruses, defined by ≥ 1.5 % nucleotide divergence in the VP1-coding region of the virus compared with the VP1 of previous circulating isolates, presents a significant challenge to polio eradication ...
Brook Tesfaye, Julius E. Chia, Terna Nomhwange, D. Collins Owuor, Ticha Johnson Muluh, Safdar Nosheen, Arthur Yannick Doungmo Wakem, Abdullateef Jimoh, Akif Saatcioglu, Kebba Touray, Abdulahi Walla Hamisu, Modjirom Ndoutabe, Jamal A. Ahmed, Anfumbom Kfutwah   +13 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Identification of Potential Vectors and Species Density of Tsetse Fly, Prevalence, and Genetic Diversity of Drug-Resistant Trypanosomes in Kenya

Pathogens
Tsetse flies are major vectors of trypanosomes in Sub-Saharan Africa, posing risks to livestock and human health. This study investigated the diversity, distribution, and infection rates of tsetse species, as well as the genetic diversity of drug ...
Ivy S. Okello, Samuel G. Onyoyo, Isaiah N. Kiteto, Sylvia M. Korir, Seth. O. Onyango   +4 more
doaj   +1 more source

Eradication of spontaneous malignancy by local immunotherapy

Science Translational Medicine, 2018
In situ vaccination with low doses of TLR ligands and anti-OX40 antibodies can cure widespread cancers in preclinical models. Deliver locally, act globally Mobilizing endogenous T cells to fight tumors is the goal of many immunotherapies.
Idit Sagiv-Barfi, D. Czerwinski, S. Levy, Israt S. Alam, Aaron T. Mayer, S. Gambhir, R. Levy   +6 more
semanticscholar   +1 more source

Photothermal‐Activated Antibacterial Amyloid‐Polyphenol‐Iron Hydrogels for Synergistic Wound Healing

Advanced Healthcare Materials, EarlyView.
We report a thermally triggered supramolecular hydrogel (LTFe) formed by Fe3+ and tannic acid on lysozyme amyloid fibrils. Fe3+ enables rapid gelation and photothermal transduction with an efficiency of 88.56%. The LTFe hydrogel exhibits excellent biocompatibility, potent antibacterial activity against E. coli and S.
Di Wu, Jiangtao Zhou, Yang Shen, Qiyao Sun, Tong Li, Xiaoyang Zou, Bin Liu, Hongshan Liang, Raffaele Mezzenga   +8 more
wiley   +1 more source

Spread and Damage of Citrus Longhorned Beetle [Anoplophora chinensis (Forster, 1771) (Coleoptera: Cerambycidae)] to Hazelnut Orchards in Turkey

Turkish Journal of Agriculture: Food Science and Technology, 2022
Turkey is the largest hazelnut producer, and the Trabzon is one of the important provinces with an annual production of 47.000 tons. The citrus longhorned beetle [Anoplophora chinensis (Forster, 1771) (Coleoptera: Cerambycidae)] is not an indigenous pest
Ali Turan, Veli Erdoğan
doaj   +1 more source