Results 91 to 100 of about 39,620 (261)

Circadian Deregulation in Multiple Myeloma: BMAL1/CLOCK Expression Patterns and Diagnostic Performance

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Background Circadian clock disruption has emerged as a relevant axis in cancer; however, the expression patterns and diagnostic relevance of BMAL1 and CLOCK in multiple myeloma (MM) remain insufficiently defined. Methods BMAL1 and CLOCK mRNA expression was quantified by RT‐qPCR in bone marrow samples from 46 newly diagnosed MM patients and 13 ...
Hamide Albayrak, Mustafa Ertan Ay, Anıl Tombak, Kenan Çevik, Özlem İzci Ay, Tuba Kabasakal, Mehmet Emin Erdal   +6 more
wiley   +1 more source

Emerging Roles of PSTPIP2 in Autoimmunity: From Mechanism to Therapeutic Implications

Immunology, EarlyView.
PSTPIP2 acts as a key brake on myeloid inflammation by suppressing IL‐1β‐driven signalling, macrophage dysregulation and inflammation‐associated bone remodelling. Its emerging roles in CRMO/CMO, rheumatoid arthritis, SAPHO syndrome and bullous pemphigoid support its potential as a biomarker and therapeutic target.
Erdong Zhang, Fengyu Liu, Yongle Wei, Guoqiang Li, Liujie Zheng, Lin Jin, Feng Luan, Yingze Zhang, Ling Wang, Zhiyong Hou   +9 more
wiley   +1 more source

C-ERB B2 EXPRESSION IN COLORECTAL CARCINOMA; ITS RELATIONSHIP WITH TUMOR GRADE AND OTHER PROGNOSTIC FACTORS

Sabiad
Objective: The multidisciplinary management of colorectal carcinoma (CRC) is based on tumor stage, grade, and presence of vascular invasion. In this approach, information derived from the molecular characteristics of the tumor may be missed.
Neslihan Şengül Şimşek, Mehmet Yaldız   +1 more
doaj   +1 more source

Mental disorders in childhood or adolescence and subsequent comprehensive school achievement

Journal of Child Psychology and Psychiatry, EarlyView.
Background Childhood mental disorders are associated with poorer school achievement, with potential negative long‐term socio‐economic consequences, but few large‐scale studies have examined this association, particularly the role of age at onset.
Yan Li, Ripsa Niemi, Mai Gutvilig, Marko Elovainio, Marjo Flykt, Christian Hakulinen   +5 more
wiley   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source

Size, not phylogeny, explains the morphology of the endosseous labyrinth in the crown clade Crocodylia

Journal of Anatomy, Volume 246, Issue 4, Page 558-574, April 2025.
Here, we present the most complete dataset to date on the endosseous labyrinths of extant crocodylians. Using 3D geometric morphometrics, we show that allometry constitutes a major contributor of the shape variation of the crocodylian endosseous labyrinths and that the development of this structure is likely linked to the braincase conformation, in all
Yohan Pochat‐Cottilloux, Gwendal Perrichon, Lionel Hautier, Nicolas Rinder, Romain Amiot, Irena Raselli, Jérôme Adrien, Joël Lachambre, Vincent Fernandez, Jeremy E. Martin   +9 more
wiley   +1 more source

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source

Endocranial anatomy of the earliest Cretaceous European neosuchian crocodyliform Pholidosaurus purbeckensis provides new evidence for the ecological evolution of Pholidosauridae

Journal of Anatomy, EarlyView.
We present new insights into the internal cranial anatomy of the neosuchian crocodyliform Pholidosaurus purbeckensis, based on CT‐scan data of material from the lowermost Cretaceous Purbeck Limestone Group, southern UK. From the study of the endocast, we obtained new information on the phylogeny and the ecological evolution of the Family ...
Leonardo Barbini, Paul M. J. Burke, Ilaria Caddeo, Marco Romano, Philip D. Mannion   +4 more
wiley   +1 more source

Computed tomography reveals the endocranial anatomy of Crocodylia: Implications for phylogenetic relationships and ecomorphological convergence across Crocodylomorpha

Journal of Anatomy, EarlyView.
The evaluation of the endocranial anatomy of 43 crocodylian species reveals several differences, including variation in the curvature of the encephalic endocast, the size of the endosseous labyrinth and paratympanic sinuses, and the presence of additional snout sinuses.
Paul M. J. Burke, Philip D. Mannion
wiley   +1 more source

Earthworm‐Inspired Ultra‐Durable Sliding Triboelectric Nanogenerator with Bionic Self‐Replenishing Lubricating Property for Wind Energy Harvesting and Self‐Powered Intelligent Sports Monitoring

Advanced Science
Triboelectric nanogenerators (TENGs), a promising strategy for harvesting distributed low‐quality power sources, face inevitable bottlenecks regarding long‐term abrasion and poor durability.
Mengjiao Liu, Xin Zhang, Yue Xin, Dongxu Guo, Guangkai Hu, Yifei Ma, Bin Yu, Tao Huang, Chengchang Ji, Meifang Zhu, Hao Yu   +10 more
doaj   +1 more source