REV-ERB activation as a novel pharmacological approach for treating inflammatory pain [PDF]
Frontiers in Pharmacology, 2023 Pain is a complex problem affecting millions of people worldwide. The current therapies to reduce pain are limited as many treatment options inadequately address the causes of pain, lead to tolerance of the drug, or have adverse effects including abuse ...
Kristine Griffett +2 more
exaly +4 more sources
Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome [PDF]
Molecular Metabolism, 2017 Objective: The loss of skeletal muscle mass and strength are a central feature of traumatic injury and degenerative myopathies. Unfortunately, pharmacological interventions typically fail to stem the long-term decline in quality of life.
Marvin Meyers +2 more
exaly +4 more sources
REV-ERB is essential in cardiac fibroblasts homeostasis [PDF]
Frontiers in Pharmacology, 2022 REV-ERB agonists have shown antifibrotic effects in the heart and other organs. The function of REV-ERB in the cardiac fibroblasts remains unstudied. Here, we characterize the functional difference of REV-ERB in mouse embryonic fibroblasts and cardiac ...
Xiaokang Luo +11 more
doaj +2 more sources
SR9009 improves heart function after pressure overload independent of cardiac REV-ERB [PDF]
Frontiers in Cardiovascular Medicine, 2022 The core clock component REV-ERB is essential for heart function. Previous studies show that REV-ERB agonist SR9009 ameliorates heart remodeling in the pressure overload model with transverse aortic constriction (TAC).
Hui Li +10 more
doaj +2 more sources
Exercise alters the circadian rhythm of REV-ERB-α and downregulates autophagy-related genes in peripheral and central tissues [PDF]
Scientific Reports, 2022 The transcriptional repressor REV-ERB-α, encoded by Nuclear Receptor Subfamily 1 Group D Member 1 (Nr1d1), has been considered to play an essential role in the skeletal muscle oxidative capacity adaptation and muscle mass control.
Alisson L. da Rocha +12 more
doaj +2 more sources
REV-ERB agonism improves liver pathology in a mouse model of NASH [PDF]
PLoS ONE, 2020 Non-alcoholic fatty liver disease (NAFLD) affects a significant number of people worldwide and currently there are no pharmacological treatments. NAFLD often presents with obesity, insulin resistance, and in some cases cardiovascular diseases. There is a
Kristine Griffett +4 more
doaj +3 more sources
Normal circadian period length requires repression of Npas2 by REV-ERB nuclear receptors [PDF]
Cell ReportsSummary: REV-ERB nuclear receptors are integrated into the molecular circadian clock present in most mammalian cells. Loss of REV-ERBs (REV-ERB DKO) within the suprachiasmatic nucleus (SCN) in vivo leads to a marked shortening of the circadian period ...
Michael C. Tackenberg +5 more
doaj +2 more sources
Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review [PDF]
Frontiers in Cardiovascular MedicineCircadian rhythm, or the biological clock, is an intrinsic timing system present in organisms that operates on a cycle of approximately 24 h. Nearly every cell in the human body adheres to a specific circadian rhythm, governing various biological ...
Chunling Wang +11 more
doaj +2 more sources
Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB [PDF]
Nature Communications, 2022 The nuclear receptor REV-ERBα is a receptor for heme and plays a role in a range of physiological processes. Here, the authors provide the first structure of REV-ERB bound to a synthetic nonporphyrin ligand defining key mechanistic differences to how ...
Meghan H. Murray +10 more
doaj +2 more sources
The Small Molecule SR8278 Inhibits Cell Proliferation Independent of the REV-ERB Nuclear Receptor Proteins in Human Keratinocytes [PDF]
BiomoleculesThe small molecule SR8278 was initially identified as an antagonist of the REV-ERB (reverse c-ERBAa) nuclear receptor proteins, which play important roles in metabolism and circadian rhythms.
Ushaswini Atluri +2 more
doaj +2 more sources