Targeting metabolic vulnerabilities: REV-ERB agonist SR9009 potentiates sorafenib efficacy in liver cancer [PDF]
Cell Death DiscoveryHepatocellular carcinoma (HCC) is one of the most common cancers and the third leading cause of cancer-related death worldwide. The prognosis is poor, with a median survival of 12–15 months in patients with advanced-stage disease. Early diagnosis and the
Silvia Sabbioni +18 more
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The Role of REV-ERB Receptors in Cancer Pathogenesis. [PDF]
Int J Mol Sci, 2023 REV-ERB receptors are members of the nuclear receptor superfamily of proteins, which act as both intracellular receptors and transcription factors, therefore modulating the expression of target genes. REV-ERBs act as transcription repressors because of their unique structure.
Gomatou G +5 more
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Chemotherapeutic Effect of SR9009, a REV-ERB Agonist, on the Human Glioblastoma T98G Cells [PDF]
ASN Neuro, 2019 Glioblastoma multiforme is the most aggressive brain tumor, and human T98G cells constitute a useful glioblastoma multiforme model to evaluate the chemotherapeutic agents.
Paula M. Wagner +2 more
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The REV-ERB Nuclear Receptors: Timekeepers for the Core Clock Period and Metabolism
Endocrinology, 2023 Marine Adlanmerini +2 more
exaly +2 more sources
SR9009 has REV-ERB–independent effects on cell proliferation and metabolism [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Marine Adlanmerini +2 more
exaly +2 more sources
Role of Circadian Transcription Factor Rev-Erb in Metabolism and Tissue Fibrosis. [PDF]
Int J Mol Sci, 2022 Circadian rhythms significantly affect metabolism, and their disruption leads to cardiometabolic diseases and fibrosis. The clock repressor Rev-Erb is mainly expressed in the liver, heart, lung, adipose tissue, skeletal muscles, and brain, recognized as a master regulator of metabolism, mitochondrial biogenesis, inflammatory response, and fibrosis ...
Raza GS, Sodum N, Kaya Y, Herzig KH.
europepmc +4 more sources
Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells. [PDF]
PLoS ONE, 2013 Disruption of pancreatic clock genes impairs pancreatic beta-cell function, leading to the onset of diabetes. Despite the importance of pancreatic alpha-cells in the regulation of glucose homeostasis and in diabetes pathophysiology, nothing is known ...
Elaine Vieira +8 more
doaj +1 more source
REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity. [PDF]
Nature, 2021 Systemic insulin sensitivity shows a diurnal rhythm with a peak upon waking1,2. The molecular mechanism that underlies this temporal pattern is unclear. Here we show that the nuclear receptors REV-ERB-α and REV-ERB-β (referred to here as 'REV-ERB') in the GABAergic (γ-aminobutyric acid-producing) neurons in the suprachiasmatic nucleus (SCN) (SCNGABA ...
Ding G +22 more
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Biology, 2021 Long-term continuous light exposure (CL) and western diet (WD) effects on Adropin expression, RORα, and Rev-erb-α nuclear receptors and energy homeostasis were studied in rats.
Mahmoud Mustafa Ali Abulmeaty +8 more
doaj +1 more source
Altered clock gene expression in obese visceral adipose tissue is associated with metabolic syndrome. [PDF]
PLoS ONE, 2014 Clock gene expression was associated with different components of metabolic syndrome (MS) in human adipose tissue. However, no study has been done to compare the expression of clock genes in visceral adipose tissue (VAT) from lean and obese subjects and ...
Elaine Vieira +8 more
doaj +1 more source