Chronic low-dose REV-ERBs agonist SR9009 mitigates constant light-induced weight gain and insulin resistance via adipogenesis modulation [PDF]
Biomedical JournalBackground: Obesity and circadian rhythm disruption are significant global health concerns, contributing to an increased risk of metabolic disorders. Both adipose tissue and circadian rhythms play critical roles in maintaining energy homeostasis, and ...
Ming-Luen Hu +2 more
exaly +7 more sources
SR9009 improves heart function after pressure overload independent of cardiac REV-ERB
Frontiers in Cardiovascular Medicine, 2022 The core clock component REV-ERB is essential for heart function. Previous studies show that REV-ERB agonist SR9009 ameliorates heart remodeling in the pressure overload model with transverse aortic constriction (TAC).
Lilei Zhang, Hui Li, Zheng Sun
exaly +7 more sources
Frontiers in Pharmacology, 2023 Backgrounds: The circadian clock protein Rev-erbα is a crucial regulator of circadian rhythms that affects multiple molecular, cellular, and physiology pathways that control susceptibility, injury, and recovery in the neurological disorders.
Gangling Chen, Xun Chen, Kou Junping
exaly +6 more sources
Cell Death and Disease, 2022 Perturbations of the circadian clock are linked to multiple diseases, including cancers. Pharmacological activation of REV-ERB nuclear receptors, the core components of the circadian clock, has antitumor effects on various malignancies, while the impact ...
Lu Yang, Jianzhong Ai, Qiang Wei
exaly +5 more sources
Time of day dependent reduction in stroke infarct volume by the Reverb agonist SR9009 in mice [PDF]
Experimental NeurologyIschemic stroke leads to disability and death worldwide and evidence suggests that stroke severity is affected by the time dimension of the stroke.
Krishnan Dhandapani +2 more
exaly +5 more sources
SR9009 attenuates inflammation-related NPMSC pyroptosis and IVDD through NR1D1/NLRP3/IL-1β pathway
iScienceSummary: Intervertebral disc is a highly rhythmical tissue. As a key factor linking biorhythm and inflammatory response, the shielding effect of NR1D1 in the process of intervertebral disc degeneration remains unclear. Here, we first confirmed that NR1D1
Ze-Nan Huang +9 more
doaj +5 more sources
SR9009 Regulates Acute Lung Injury in Mice Induced by Sepsis
Canadian Respiratory Journal, 2022 Rev-Erbα is a nuclear heme receptor, transcriptional repressor, and critical component of the molecular clock that drives daily rhythms of metabolism. However, the roles of Rev-Erbα in acute lung injury (ALI) remain unclarified.
Ming Hu +4 more
doaj +4 more sources
Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence [PDF]
Aging Cell, 2021 The senescence‐associated secretory phenotype (SASP) is a striking characteristic of senescence. Accumulation of SASP factors causes a pro‐inflammatory response linked to chronic disease.
Yu Sun, Libin Gao, Qing Jing
exaly +4 more sources
Chemotherapeutic Effect of SR9009, a REV-ERB Agonist, on the Human Glioblastoma T98G Cells [PDF]
ASN Neuro, 2019 Glioblastoma multiforme is the most aggressive brain tumor, and human T98G cells constitute a useful glioblastoma multiforme model to evaluate the chemotherapeutic agents.
Paula M. Wagner +2 more
doaj +6 more sources
SR9009 has REV-ERB–independent effects on cell proliferation and metabolism [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance SR9009 has been described as an agonist for circadian nuclear receptors REV-ERBα and -β, and its pleotropic biological effects have been attributed to REV-ERBs in numerous publications, as well as websites selling the compound illicitly to ...
Marine Adlanmerini +2 more
exaly +4 more sources