Results 11 to 20 of about 766 (143)

Time-dependent effect of REV-ERBα agonist SR9009 on nonalcoholic steatohepatitis and gut microbiota in mice

Chronobiology International, 2023
The circadian clock is involved in the pathogenesis of nonalcoholic steatohepatitis (NASH), and the target pathways of many NASH candidate drugs are controlled by the circadian clock.
Ni Yinhua, Zhengwei Fu, Liujie Zheng
exaly   +4 more sources

In Vitro Metabolic Studies of REV-ERB Agonists SR9009 and SR9011 [PDF]

International Journal of Molecular Sciences, 2016
SR9009 and SR9011 are attractive as performance-enhancing substances due to their REV-ERB agonist effects and thus circadian rhythm modulation activity.
Lore Geldof, Koen Deventer
exaly   +5 more sources

A further insight into the metabolic profile of the nuclear receptor Rev‐erb agonist, SR9009 [PDF]

Drug Testing and Analysis, 2018
The reactions involved in the metabolic pathways of SR9009 were characterized by liquid chromatography-mass spectrometry (LC-MS) to identify the most appropriate marker(s) of use.
Francesco Botre, Xavier De La Torre, Carlotta Stacchini   +2 more
exaly   +5 more sources

SR9009 regulates macrophage polarization via the NR1D1/NF-κB axis to ameliorate obesity-associated ulcerative colitis

Frontiers in Gastroenterology
ObjectiveThe incidence of ulcerative colitis (UC) and obesity has risen in recent years, potentially linked through metabolic dysregulation and chronic inflammation.
Zhixue Zheng, Xuan Cai, Yaqi Liu, Jingtao Bi   +3 more
doaj   +3 more sources

Circadian Clock REV-ERBs Agonist SR9009 Induces Synergistic Antitumor Activity in Multiple Myeloma by Suppressing Glucose-Regulated Protein 78-Dependent Autophagy and Lipogenesis. [PDF]

World J Oncol, 2023
Background Proteasome inhibitors, such as bortezomib, have demonstrated efficacy in the therapeutic management of multiple myeloma (MM). However, it is important to note that these inhibitors also elicit endoplasmic reticulum stress, which subsequently ...
Wang R, Liu SL, Guo QQ, Shi XH, Ma MM.
europepmc   +4 more sources

Targeting metabolic vulnerabilities: REV-ERB agonist SR9009 potentiates sorafenib efficacy in liver cancer

Cell Death Discovery
Hepatocellular carcinoma (HCC) is one of the most common cancers and the third leading cause of cancer-related death worldwide. The prognosis is poor, with a median survival of 12–15 months in patients with advanced-stage disease. Early diagnosis and the
Silvia Sabbioni, Paola Guerriero, Ram C. Shankaraiah, Laura Masatti, Angelo Michilli, Cristian Bassi, Lucilla D’Abundo, Farzaneh Moshiri, Bruno De Siena, Edi Simoni, Laura Astolfi, Laura Gramantieri, Roberta Roncarati, Bahaeldin K. Elamin, Massimo Bonora, Paolo Pinton, Carlo M. Croce, Massimo Negrini, Elisa Callegari   +18 more
doaj   +5 more sources

SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy

Theranostics, 2020
Rationale: The circadian clock coordinates cell proliferation and metabolism and impacts the progression of some diseases, particularly cancer. Pharmacological modulation of the circadian machinery may be an effective therapeutic approach for treating ...
Wen Ge, Jie Shen, Weitao Shen
exaly   +4 more sources

Rev-erbs agonist SR9009 alleviates ischemia-reperfusion injury by heightening endogenous cardioprotection at onset of type-2 diabetes in rats: Down-regulating ferritinophagy/ferroptosis signaling

Biomedicine and Pharmacotherapy, 2022
The complex progression of type-2 diabetes (T2DM) results in inconsistent findings on myocardial susceptibility to ischemia-reperfusion (IR). IR injuries in multiple organs interconnect with ferroptosis.
Zhen Qiu
exaly   +4 more sources

SR9009 administered for one day after myocardial ischemia-reperfusion prevents heart failure in mice by targeting the cardiac inflammasome [PDF]

Communications Biology, 2019
Reperfusion of patients after myocardial infarction (heart attack) triggers cardiac inflammation that leads to infarct expansion and heart failure (HF).
Cristine Reitz, Faisal Alibhai, Tami A Martino   +2 more
exaly   +5 more sources

Genetic disruption of the circadian gene Bmal1 in the intestinal epithelium reduces colonic inflammation [PDF]

EMBO Reports
Disruption of the circadian clock is associated with the development of inflammatory bowel disease (IBD), but the underlying mechanisms remain unclear. Here, we observe that mice in the early active phase (Zeitgeber time 12, ZT12) of the circadian clock ...
Shan Hua, Ze Zhang, Zhe Zhang, Liansheng Liu, Shicheng Yu, Yanhui Xiao, Yuan Liu, Siting Wei, Ying Xu, Ye-Guang Chen   +9 more
doaj   +3 more sources