Results 41 to 50 of about 766 (143)

IL-6 deletion decreased REV-ERBα protein and influenced autophagy and mitochondrial markers in the skeletal muscle after acute exercise

Frontiers in Immunology, 2022
Interleukin 6 (IL-6) acts as a pro and anti-inflammatory cytokine, has an intense correlation with exercise intensity, and activates various pathways such as autophagy and mitochondrial unfolded protein response. Also, IL-6 is interconnected to circadian
Ana P. Pinto, Vitor R. Muñoz, Alisson L. da Rocha, Rafael L. Rovina, Gustavo D. Ferrari, Luciane C. Alberici, Fernando M. Simabuco, Fernando M. Simabuco, Giovana R. Teixeira, Giovana R. Teixeira, José R. Pauli, Leandro P. de Moura, Dennys E. Cintra, Eduardo R. Ropelle, Ellen C. Freitas, Donato A. Rivas, Adelino S. R. da Silva, Adelino S. R. da Silva   +17 more
doaj   +1 more source

Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation. [PDF]

PLoS ONE, 2016
The circadian clock maintains appropriate timing for a wide range of behaviors and physiological processes. Circadian behaviors such as sleep and wakefulness are intrinsically dependent on the precise oscillation of the endogenous molecular machinery ...
Ariadna Amador, Salvador Huitron-Resendiz, Amanda J Roberts, Theodore M Kamenecka, Laura A Solt, Thomas P Burris   +5 more
doaj   +1 more source

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells

iScience, 2021
Summary: The coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) coronavirus, is a global health issue with unprecedented challenges for public health.
Xiaodong Zhuang, Senko Tsukuda, Florian Wrensch, Peter A.C. Wing, Mirjam Schilling, James M. Harris, Helene Borrmann, Sophie B. Morgan, Jennifer L. Cane, Laurent Mailly, Nazia Thakur, Carina Conceicao, Harshmeena Sanghani, Laura Heydmann, Charlotte Bach, Anna Ashton, Steven Walsh, Tiong Kit Tan, Lisa Schimanski, Kuan-Ying A. Huang, Catherine Schuster, Koichi Watashi, Timothy S.C. Hinks, Aarti Jagannath, Sridhar R. Vausdevan, Dalan Bailey, Thomas F. Baumert, Jane A. McKeating   +27 more
doaj   +1 more source

Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression. [PDF]

PLoS ONE, 2016
The nuclear receptors REV-ERBα and REV-ERBβ are transcription factors that play pivotal roles in the regulation of the circadian rhythm and various metabolic processes.
Ariadna Amador, Yongjun Wang, Subhashis Banerjee, Theodore M Kameneka, Laura A Solt, Thomas P Burris   +5 more
doaj   +1 more source

REV-ERB activation as a novel pharmacological approach for treating inflammatory pain

Frontiers in Pharmacology, 2023
Pain is a complex problem affecting millions of people worldwide. The current therapies to reduce pain are limited as many treatment options inadequately address the causes of pain, lead to tolerance of the drug, or have adverse effects including abuse ...
Sangeet Makhija, Joshua D. Griffett, Giri Babu Veerakanellore, Giri Babu Veerakanellore, Thomas P. Burris, Bahaa Elgendy, Bahaa Elgendy, Kristine Griffett   +7 more
doaj   +1 more source

Nuclear receptor subfamily 1 group D member 1 suppresses the proliferation, migration of adventitial fibroblasts, and vascular intimal hyperplasia via mammalian target of rapamycin complex 1/β-catenin pathway

Clinical and Experimental Hypertension, 2023
Background In-stent restenosis hardly limits the therapeutic effect of the percutaneous vascular intervention. Although the restenosis is significantly ameliorated after the application of new drug-eluting stents, the incidence of restenosis remains at a
Ke Peng, Mingliang Wang, Jun Wang, Qiang Wang, De Li, Xiongshan Sun, Yongjian Yang, Dachun Yang   +7 more
doaj   +1 more source

REV-ERB is essential in cardiac fibroblasts homeostasis

Frontiers in Pharmacology, 2022
REV-ERB agonists have shown antifibrotic effects in the heart and other organs. The function of REV-ERB in the cardiac fibroblasts remains unstudied. Here, we characterize the functional difference of REV-ERB in mouse embryonic fibroblasts and cardiac ...
Xiaokang Luo, Shiyang Song, Lei Qi, Chih-Liang Tien, Hui Li, Weiyi Xu, Theodore Lemuel Mathuram, Thomas Burris, Yuanbiao Zhao, Zheng Sun, Zheng Sun, Lilei Zhang   +11 more
doaj   +1 more source

Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model

Journal of Neuroinflammation, 2020
Background A hallmark of temporal lobe epilepsy (TLE) is brain inflammation accompanied by neuronal demise. Accumulating evidence demonstrates that Rev-Erbα is involved in regulating neuroinflammation and determining the fate of neurons.
Jiong Yue, Jiaojiang He, Yujia Wei, Kaifeng Shen, Kefu Wu, Xiaolin Yang, Shiyong Liu, Chunqing Zhang, Hui Yang   +8 more
doaj   +1 more source

REV-ERB agonism improves liver pathology in a mouse model of NASH.

PLoS ONE, 2020
Non-alcoholic fatty liver disease (NAFLD) affects a significant number of people worldwide and currently there are no pharmacological treatments. NAFLD often presents with obesity, insulin resistance, and in some cases cardiovascular diseases. There is a
Kristine Griffett, Gonzalo Bedia-Diaz, Bahaa Elgendy, Thomas P Burris   +3 more
doaj   +2 more sources

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease.

PLoS ONE, 2019
Alzheimer's disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease.
Deborah A Roby, Fernanda Ruiz, Bailey A Kermath, Jaymie R Voorhees, Michael Niehoff, Jinsong Zhang, John E Morley, Erik S Musiek, Susan A Farr, Thomas P Burris   +9 more
doaj   +1 more source