Results 21 to 30 of about 766 (143)

Rhythms under tension: Circadian clocks in an Unsynced Society [PDF]

Biomedical Journal
This special issue of the Biomedical Journal centers on circadian rhythms, examining the molecular mechanisms of the circadian clock, the consequences of circadian disruption, and their implications for health and disease.
Aila Akosua Kattner
doaj   +3 more sources

REV-ERBα Agonist SR9009 Promotes a Negative Energy Balance in Goldfish

International Journal of Molecular Sciences, 2022
REV-ERBα (nr1d1, nuclear receptor subfamily 1 group D member 1) is a transcriptional repressor that in mammals regulates nutrient metabolism, and has effects on energy homeostasis, although its role in teleosts is poorly understood. To determine REV-ERBα’
N. Saiz, L. Herrera-Castillo, E. Isorna, M. Delgado, Marta Conde-Sieira, J. Soengas, N. de Pedro   +6 more
semanticscholar   +5 more sources

Targeting Rev-Erbα to protect against ischemia-reperfusion-induced acute lung injury in rats [PDF]

Respiratory Research, 2023
Background The dysregulation of local circadian clock has been implicated in the pathogenesis of a broad spectrum of diseases. However, the pathophysiological role of intrinsic circadian clocks Rev-Erbα in ischemia-reperfusion (IR)-induced acute lung ...
Shi-Jye Chu, Wen-I Liao, Hsin-Ping Pao, Shu-Yu Wu, Shih-En Tang   +4 more
doaj   +2 more sources

Exhaustive exercise abolishes REV-ERB-α circadian rhythm and shifts the kynurenine pathway to a neurotoxic profile in mice. [PDF]

J Physiol
Abstract figure legend Acute exhaustive exercise (EE) reduces REV‐ERB‐α protein levels in skeletal muscle, which impairs its transcriptional repression of kynurenine (KYN) 3‐monooxygenase (KMO), a key enzyme in the KYN pathway that converts KYN into potentially neurotoxic metabolites, collectively referred to as ‘kynurenines’. This study identifies KMO
da Rocha AL, Pinto AP, de Sousa Neto IV, Muñoz VR, Marafon BB, da Silva LECM, Pauli JR, Cintra DE, Ropelle ER, Simabuco FM, de Moura LP, de Freitas EC, Rivas DA, da Silva ASR.   +13 more
europepmc   +2 more sources

The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson’s disease via the microglial NLRP3 inflammasome

Journal of Neuroinflammation, 2022
Background Circadian disturbance is a common nonmotor complaint in Parkinson’s disease (PD). The molecular basis underlying circadian rhythm in PD is poorly understood. Neuroinflammation has been identified as a key contributor to PD pathology.
Liang Kou, Xiaosa Chi, Yadi Sun, Chao Han, Fang Wan, Junjie Hu, Sijia Yin, Jiawei Wu, Yunna Li, Qiulu Zhou, Wenkai Zou, Nian Xiong, Jinsha Huang, Yun Xia, Tao Wang   +14 more
doaj   +2 more sources

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling. [PDF]

Adv Sci (Weinh)
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Chen M, Zhang F, Xiao Y, Jiang X, Yan Z, Wang J, Lv X, Cui J, Ha L, Chen H, Dang Y, Qin Z, Yang J, Wu B.   +13 more
europepmc   +2 more sources

Rev-erb agonist SR9009 inhibits the proliferation of human colon cancer cell line HCT116 through reducing autophagy [PDF]

Jichu yixue yu linchuang, 2020
Objective To investigate the effect of hemeregulated nuclear receptor(Rev-erb) agonist SR9009 on the proliferation and potential mechanism of human colon cancer cell line HCT116.
SHI Guang, NING Na, HOU Xiao-hong, SUN Cong, YUAN Yuan, WANG Li, WANG Xiao-hui
doaj   +1 more source

The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock [PDF]

International Journal of Molecular Sciences, 2019
The cell-autonomous circadian clock regulates IgE- and IL-33-mediated mast cell activation, both of which are key events in the development of allergic diseases. Accordingly, clock modifiers could be used to treat allergic diseases, as well as many other
Kayoko Ishimaru, S. Nakajima, Guannan Yu, Yuki Nakamura, A. Nakao   +4 more
semanticscholar   +3 more sources

A theoretical systems chronopharmacology approach for COVID-19: Modeling circadian regulation of lung infection and potential precision therapies. [PDF]

CPT Pharmacometrics Syst Pharmacol
Abstract The COVID‐19 pandemic, caused by SARS‐CoV‐2, has underscored the urgent need for innovative therapeutic approaches. Recent studies have revealed a complex interplay between the circadian clock and SARS‐CoV‐2 infection in lung cells, opening new avenues for targeted interventions.
Tseng YY.
europepmc   +2 more sources

Pharmacological modulation of circadian rhythms in brain microvasculature. [PDF]

J Cereb Blood Flow Metab
The interface between the blood and brain is vital for the protection of neurological processes. A key regulatory mechanism of the blood–brain border (BBB) is the circadian rhythm, an intrinsic timekeeping system that maintains 24-h rhythms.
Yang Z, Kim M, Montgomery M, Lewandowski A, Ho A, Buchwald ZS, Zhang SL.   +6 more
europepmc   +2 more sources