Results 31 to 40 of about 766 (143)

Limited effects of the REV-ERB agonist SR9009 after mouse spinal cord contusion: Reduced acute pathology with unaffected functional recovery and chronic white matter loss.

Neuroscience Letters
The ligand-regulated transcription factors REV-ERBα/NR1D1 and REV-ERBβ/NR1D2 are promising neuroprotective targets. Systemic administration of the REV-ERB agonist SR9009 has been shown to reduce neuroinflammation, limit tissue loss, and enhance ...
L. Slomnicki, Emily R. Hodges, Christine Armstrong, Johnny Morehouse, Darlene A. Burke, S. Ohri, T.P. Burris, Michal Hetman   +7 more
semanticscholar   +3 more sources

An HPLC–HRMS profiling of dietary supplements declaring andarine (S-4)

Reviews in Analytical Chemistry
Selective androgen receptor modulators (SARMs), including andarine (S-4), have gained significant attention in the dietary supplement market despite their known health risks and prohibition in competitive sports.
Slíž Kristián, Mikuš Peter
doaj   +2 more sources

Retraction notice to "SR9009 attenuates inflammation-related NPMSC pyroptosis and IVDD through NR1D1/NLRP3/IL-1β pathway" [iScience 27 (2024) 109733].

iScience
[This retracts the article DOI: 10.1016/j.isci.2024.109733.].
Zenan Huang, Jing Wang, Ze-yu Wang, Ling-yuan Min, Hai Ni, Yan-Ling Han, You-yue Tian, Ya-Zhou Cui, Jing-Xiang Han, Xiao-Fei Cheng   +9 more
semanticscholar   +2 more sources

Targeting Circadian Protein Rev-erbα to Alleviate Inflammation, Oxidative Stress, and Enhance Functional Recovery Following Brain Trauma [PDF]

Antioxidants
Traumatic brain injury (TBI) is a significant cause of morbidity and mortality worldwide, and its pathophysiology is characterized by oxidative stress and inflammation. Despite extensive research, effective treatments for TBI remain elusive.
Arief Gunawan Darmanto, Jing-Shiun Jan, Ting-Lin Yen, Shin-Wei Huang, Ruei-Dun Teng, Jia-Yi Wang, Rajeev Taliyan, Joen-Rong Sheu, Chih-Hao Yang   +8 more
doaj   +2 more sources

Nuclear receptor Rev-erbα alleviates intervertebral disc degeneration by recruiting NCoR-HDAC3 co-repressor and inhibiting NLRP3 inflammasome. [PDF]

Cell Prolif
Rev‐erbα deficiency aggravates NP cell apoptosis and imbalance of extracellular matrix. Specifically, pharmacologic Rev‐erbα activation alleviates IVD degeneration via its ligand heme binding to NCoR and HDAC3 corepressor complex to repress NLRP3 inflammasome activation.
Zhou Q, Pu X, Qian Z, Chen H, Wang N, Wang S, Feng Z, Zhu Z, Wang B, Qiu Y, Sun X.   +10 more
europepmc   +2 more sources

REV-ERBα negatively regulates NLRP6 transcription and reduces the severity of Salmonella infection in mice [PDF]

Heliyon
Non-typhoidal Salmonella infection is among the most frequent foodborne diseases threatening human health worldwide. The host circadian clock orchestrates daily rhythms to adapt to environmental changes, including coordinating immune function in response
Lanqing Sun, Kai Huang, Qifeng Deng, Yuan Zhu, Yu Cao, Kedi Dong, Sidi Yang, Yuanyuan Li, Shuyan Wu, Rui Huang   +9 more
doaj   +2 more sources

Pharmacological Activation of Rev-erbα Attenuates Doxorubicin-Induced Cardiotoxicity by PGC-1α Signaling Pathway

Cardiovascular Therapeutics, 2023
Background. Doxorubicin-induced cardiotoxicity has been closely concerned in clinical practice. Rev-erbα is a transcriptional repressor that emerges as a drug target for heart diseases recently. This study is aimed at investigating the role and mechanism
Runmei Zou, Shuo Wang, Hong Cai, Yuwen Wang, Cheng Wang   +4 more
doaj   +1 more source

Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome

Frontiers in Cell and Developmental Biology, 2021
Polycystic ovary syndrome (PCOS) is an endocrinopathy with complex pathophysiology that is a common cause of anovulatory infertility in women. Although the disruption of circadian rhythms is indicated in PCOS, the role of the clock in the etiology of ...
Lihua Sun, Hui Tian, Songguo Xue, Hongjuan Ye, Xue Xue, Rongxiang Wang, Yu Liu, Caixia Zhang, Qiuju Chen, Shaorong Gao   +9 more
doaj   +1 more source

Rev-erb agonist improves adverse cardiac remodeling and survival in myocardial infarction through an anti-inflammatory mechanism. [PDF]

PLoS ONE, 2017
Rev-erb α, known as nuclear receptor 1D1 (NR1D1), regulates circadian rhythm, modulates glucose and lipid metabolism, and inflammatory response. However, little is known about the effect of Rev-erb agonist on the progression of myocardial infarction (MI)
Endin Nokik Stujanna, Nobuyuki Murakoshi, Kazuko Tajiri, DongZhu Xu, Taizo Kimura, Rujie Qin, Duo Feng, Saori Yonebayashi, Yukino Ogura, Fumi Yamagami, Akira Sato, Akihiko Nogami, Kazutaka Aonuma   +12 more
doaj   +1 more source

Pharmacological activation of rev-erbα suppresses LPS-induced macrophage M1 polarization and prevents pregnancy loss

BMC Immunology, 2021
Background Circadian rhythm is an important player for reproduction. Rev-erbα, a significant clock gene, is involved in regulating cell differentiation, inflammation and metabolism.
Liyuan Cui, Feng Xu, Songcun Wang, Xinyi Li, Haiyan Lin, Yan Ding, Meirong Du   +6 more
doaj   +1 more source