Results 1 to 10 of about 29,810 (265)

Dialkylaminoalkylation of β-ketosulfones via ring-opening of 3-sulfonylpyrrolidines [PDF]

Beilstein Journal of Organic Chemistry
Herein, a three-step method for the simultaneous dialkylaminoethylation and heteromethylation of active methylene β-ketosulfones, promoted by a leaving benzoyl group, is proposed.
Evgeny M. Buev, Alexander V. Pavlushin, Vladimir S. Moshkin, Vyacheslav Y. Sosnovskikh   +3 more
doaj   +2 more sources

Construction of N-Aryl-Substituted Pyrrolidines by Successive Reductive Amination of Diketones via Transfer Hydrogenation [PDF]

Molecules
N-aryl-substituted pyrrolidines are important moieties widely found in bioactive substances and drugs. Herein, we present a practical reductive amination of diketones with anilines for the synthesis of N-aryl-substituted pyrrolidines in good to excellent
Jianhua Liao, Jinghui Tong, Liang Liu, Lu Ouyang, Renshi Luo   +4 more
doaj   +2 more sources

One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines

Molecules, 2022
Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts ...
Qiao Song, Sheng Wang, Xiangui Lei, Yan Liu, Xin Wen, Zhouyu Wang   +5 more
doaj   +1 more source

Nitropyridines as 2π-Partners in 1,3-Dipolar Cycloadditions with N-Methyl Azomethine Ylide: An Easy Access to Condensed Pyrrolines

Molecules, 2021
1,3-Dipolar cycloaddition reactions of 2-substituted 5-R-3-nitropyridines and isomeric 3-R-5-nitropyridines with N-methyl azomethine ylide were studied. The effect of the substituent at positions 2 and 5 of the pyridine ring on the possibility of the [3 ...
Maxim A. Bastrakov, Alexey K. Fedorenko, Alexey M. Starosotnikov, Alexander Kh. Shakhnes   +3 more
doaj   +1 more source

Different Behavior of 2-Substituted 3-Nitro-2H-chromenes in the Reaction with Stabilized Azomethine Ylides Generated from α-Iminoesters

Molecules, 2022
The AgOAc-catalysed reaction of 3-nitro-2-phenyl-2H-chromenes with stabilized azomethine ylides generated from the imines based on methyl glycinate and arylaldehydes leads to a mixture of endo and endo’ isomers of the corresponding chromeno[3,4-c ...
Ivan A. Kochnev, Alexey Y. Barkov, Nikita S. Simonov, Maria V. Ulitko, Nikolay S. Zimnitskiy, Vladislav Y. Korotaev, Vyacheslav Y. Sosnovskikh   +6 more
doaj   +1 more source

Regioselective access to polycyclic N-heterocycles via homogeneous copper-catalyzed cascade cyclization of allenynes

Communications Chemistry, 2023
Polycyclic N-heterocycles are important structural motifs commonly found in bioactive compounds, however, their selective construction via the cyclization of allenynes remains challenging yet highly desirable.
Kua-Fei Wei, Qing Liu, Guang Ma, Xiao-Lei Jiang, Xiu-Hong Zhu, Guang-Xin Ru, Wen-Bo Shen   +6 more
doaj   +1 more source

Highly stereocontrolled total synthesis of racemic codonopsinol B through isoxazolidine-4,5-diol vinylation

Beilstein Journal of Organic Chemistry, 2021
A new highly diastereoselective synthesis of the polyhydroxylated pyrrolidine alkaloid (±)-codonopsinol B and its N-nor-methyl analogue, starting from achiral materials, is presented.
Lukáš Ďurina, Anna Ďurinová, František Trejtnar, Ľuboš Janotka, Lucia Messingerová, Jana Doháňošová, Ján Moncol, Róbert Fischer   +7 more
doaj   +1 more source

Synthesis of Dihydrouracils Spiro-Fused to Pyrrolidines: Druglike Molecules Based on the 2-Arylethyl Amine Scaffold

Molecules, 2010
The synthesis of a small library of dihydrouracils spiro-fused to pyrrolidines is described. These compounds are synthesized from b-aryl pyrrolidines, providing products with the 2-arylethyl amine moiety, a structural feature often encountered in ...
Daniel Blanco-Ania, Carolina Valderas-Cortina, Pedro H.H. Hermkens, Leo A.J.M. Sliedregt, Hans W. Scheeren, Floris P.J.T. Rutjes   +5 more
doaj   +1 more source

1,3-Dipolar Cycloadditions of N-Benzyl Furfuryl Nitrones with Electron-rich Alkenes

Molecules, 2000
The 1,3-dipolar cycloaddition reaction of N-benzyl-C-(2-furyl)nitrones with electron-rich alkenes gives preferentially trans-substituted 3,5-disubstituted isoxazolidines (endo approach).
Tomas Tejero, Francisco L. Merchan, Sonia Anoro, Pedro Merino   +3 more
doaj   +1 more source

Synthesis of 1-phenyl-3-pyrroline in water

Orbital: The Electronic Journal of Chemistry, 2012
Pyrrolines are bioactive compounds and can be used as starting materials or as intermediates in the synthesis of natural products [1,2]. N-phenyl-pyrrolines have been prepared by reaction of N-propargylanilines catalyzed by Cu(I) [3] or the ring-closing ...
Thiago Muniz de Souza, Ivani Malvestiti, Lothar W. Bieber   +2 more
doaj   +1 more source