Results 1 to 10 of about 26,509 (243)

Diastereoselective Preparation of Azetidines and Pyrrolidines

Organic Letters, 2010
Iodine-mediated cyclization of homoallyl amines at room temperature delivered cis-2,4-azetidine through a 4-exo trig cyclization. Isomerization of iodo-azetidines to cis-pyrrolidines could be achieved by heating, with complete stereocontrol. The relative
Antonio Feula, Louise Male, John S Fossey   +2 more
exaly   +4 more sources

Recent Advances in Intramolecular C─N Bond Formation for Pyrrolidine Synthesis [PDF]

ChemistryOpen
Pyrrolidines constitute a privileged class of nitrogen heterocycles that are ubiquitous in pharmaceuticals, bioactive molecules, and functional materials, thereby continuing to stimulate the development of efficient and versatile synthetic strategies ...
Rasma Kroņkalne, Māris Turks
doaj   +3 more sources

Telescoped Synthesis of Stereodefined Pyrrolidines

Organic Letters, 2013
Telescoped and one-pot olefination/asymmetric functionalization approaches to disubstituted pyrrolidines (dr up to 99:1, up to 99% ee) have been developed using commercially available tetramisole (0.1 to 5 mol %).
David B Cordes, Alexandra M Z Slawin, Andrew D Smith   +2 more
exaly   +4 more sources

One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines

Molecules, 2022
Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts ...
Qiao Song, Sheng Wang, Xiangui Lei, Yan Liu, Xin Wen, Zhouyu Wang   +5 more
doaj   +2 more sources

Photochemical Catalyst-Free Synthesis of Pyrrolidines via a Hofmann–Loffler–Freytag Reaction [PDF]

Molecules
The Hoffman–Loffler–Freytag (HLF) reaction is one of the first transformations to achieve remote C(sp3)-H functionalization and simultaneously provide useful building blocks from readily available reagents. Herein, we propose a photochemical protocol for
Athina S. J. Shkembi, Luca Pasqualon, Stamatis K. Serviou, Manos V. G. Lantzanakis, Christoforos G. Kokotos   +4 more
doaj   +2 more sources

Synthesis of Dihydrouracils Spiro-Fused to Pyrrolidines: Druglike Molecules Based on the 2-Arylethyl Amine Scaffold

Molecules, 2010
The synthesis of a small library of dihydrouracils spiro-fused to pyrrolidines is described. These compounds are synthesized from b-aryl pyrrolidines, providing products with the 2-arylethyl amine moiety, a structural feature often encountered in ...
Daniel Blanco-Ania, Carolina Valderas-Cortina, Pedro H.H. Hermkens, Leo A.J.M. Sliedregt, Hans W. Scheeren, Floris P.J.T. Rutjes   +5 more
doaj   +2 more sources

Dialkylaminoalkylation of β-ketosulfones via ring-opening of 3-sulfonylpyrrolidines [PDF]

Beilstein Journal of Organic Chemistry
Herein, a three-step method for the simultaneous dialkylaminoethylation and heteromethylation of active methylene β-ketosulfones, promoted by a leaving benzoyl group, is proposed.
Evgeny M. Buev, Alexander V. Pavlushin, Vladimir S. Moshkin, Vyacheslav Y. Sosnovskikh   +3 more
doaj   +2 more sources

Synthesis of a New Chiral Pyrrolidine [PDF]

Molecules, 2010
The synthesis of a new chiral pyrrolidine has been performed using 2,3-O-isopropylidene-D-erythronolactol as a suitable starting material.
Pilar García, Enrique F. Iglesias, Isidro S. Marcos, Narciso M. Garrido, Rosalina F. Moro, Marta G. Núñez, Mari Fe. Flores, David Díez   +7 more
doaj   +3 more sources

Redox-Triggered α-C–H Functionalization of Pyrrolidines: Synthesis of Unsymmetrically 2,5-Disubstituted Pyrrolidines

Organic Letters, 2015
By using o-benzoquinone as an internal oxidant, the regio- and diastereoselective functionalization of the secondary over the tertiary α-C–H bond of 2-substituted pyrrolidines is first realized.
Yong-Feng Cheng, Jin Qu
exaly   +2 more sources

Skeletal editing of tetrahydrofurans to pyrrolidines through O-to-N single atom swap [PDF]

Nature Communications
Skeletal editing has emerged as a powerful strategy for organic synthesis, addressing a long-standing synthetic challenge between molecular scaffolds.
Shihan Geng, Tieqiao Wang, Qingxuan Kong, Dunhang Ouyang, Changwei Jiang, Ning Jiao, Song Song   +6 more
doaj   +2 more sources