Results 11 to 20 of about 27,991 (255)

Photochemical Catalyst-Free Synthesis of Pyrrolidines via a Hofmann–Loffler–Freytag Reaction [PDF]

Molecules
The Hoffman–Loffler–Freytag (HLF) reaction is one of the first transformations to achieve remote C(sp3)-H functionalization and simultaneously provide useful building blocks from readily available reagents. Herein, we propose a photochemical protocol for
Athina S. J. Shkembi, Luca Pasqualon, Stamatis K. Serviou, Manos V. G. Lantzanakis, Christoforos G. Kokotos   +4 more
doaj   +2 more sources

Recent Advances in Intramolecular C─N Bond Formation for Pyrrolidine Synthesis [PDF]

ChemistryOpen
Pyrrolidines constitute a privileged class of nitrogen heterocycles that are ubiquitous in pharmaceuticals, bioactive molecules, and functional materials, thereby continuing to stimulate the development of efficient and versatile synthetic strategies ...
Rasma Kroņkalne, Māris Turks
doaj   +2 more sources

Dialkylaminoalkylation of β-ketosulfones via ring-opening of 3-sulfonylpyrrolidines [PDF]

Beilstein Journal of Organic Chemistry
Herein, a three-step method for the simultaneous dialkylaminoethylation and heteromethylation of active methylene β-ketosulfones, promoted by a leaving benzoyl group, is proposed.
Evgeny M. Buev, Alexander V. Pavlushin, Vladimir S. Moshkin, Vyacheslav Y. Sosnovskikh   +3 more
doaj   +2 more sources

Skeletal editing of tetrahydrofurans to pyrrolidines through O-to-N single atom swap [PDF]

Nature Communications
Skeletal editing has emerged as a powerful strategy for organic synthesis, addressing a long-standing synthetic challenge between molecular scaffolds.
Shihan Geng, Tieqiao Wang, Qingxuan Kong, Dunhang Ouyang, Changwei Jiang, Ning Jiao, Song Song   +6 more
doaj   +2 more sources

Synthesis of a New Chiral Pyrrolidine [PDF]

Molecules, 2010
The synthesis of a new chiral pyrrolidine has been performed using 2,3-O-isopropylidene-D-erythronolactol as a suitable starting material.
Pilar García, Enrique F. Iglesias, Isidro S. Marcos, Narciso M. Garrido, Rosalina F. Moro, Marta G. Núñez, Mari Fe. Flores, David Díez   +7 more
doaj   +3 more sources

Synthesis and Suzuki-Miyaura Cross-Coupling of α-Borylated Pyrrolidines [PDF]

, 2021
This thesis describes the steps taken towards the development of a methodology for the synthesis and Suzuki-Miyaura cross-coupling of α-borylated pyrrolidines. Two main methods were explored for the synthesis of α-borylated pyrrolidines.
Howman, Chloe Elizabeth
core   +5 more sources

One-Pot Route from Halogenated Amides to Piperidines and Pyrrolidines

Molecules, 2022
Piperidine and pyrrolidine derivatives are important nitrogen heterocyclic structures with a wide range of biological activities. However, reported methods for their construction often face problems of requiring the use of expensive metal catalysts ...
Qiao Song, Sheng Wang, Xiangui Lei, Yan Liu, Xin Wen, Zhouyu Wang   +5 more
doaj   +1 more source

Direct synthesis of functionalized 3-pyrrolidines and 4-piperidines using the borrowing hydrogen methodology [PDF]

, 2023
The Ir(III)-catalyzed synthesis of 3-pyrrolidinols and 4-piperidinols combining 1,2,4-butanetriol or 1,3,5-pentanetriol with primary amines was carried out.
Florence, Popowycz, Maiwenn, Jacolot, Jordan, François, Malvina, Larduinat   +3 more
core   +1 more source

Enantioselective Synthesis of Pyrrolidines by Imidodiphosphorimidate (IDPi)-catalysed anti-hydroamination of alkenes [PDF]

, 2023
Chiral pyrrolidines are common structural motives in natural products as well as active pharmaceutical ingredients explaining the need for methods for their enantioselective synthesis.
Ruben, Van Lommel, Constantin G., Daniliuc, Ulrich, Hennecke, Raffi, Khudaverdyan, Alexander N., Volkov, Frank, De Proft, Sudip, Guria   +6 more
core   +2 more sources

Brønsted base-catalyzed assembly of sulfochromeno [4,3-b] pyrrolidines via tandem [3+2] cycloaddition-SuFEx click reaction of ethenesulfonyl fluorides and azomethine ylides [PDF]

, 2022
The synthesis of sulfochromeno [4,3-b] pyrrolidines is described. Under the catalysis of 20 mol% Brønsted base and using 4Å molecular sieves as HF scavenger, imines derived from salicylaldehydes and diethyl aminomalonate react with ethenesulfonyl ...
Qichao, Zhang, Jichang, Liu, Fang, Zhang, Lin, He, Bin, Dai   +4 more
core   +2 more sources