Results 41 to 50 of about 29,047 (251)
Molecules, 2020 The reaction of meso-tetrakis(pentafluorophenyl)porpholactone with azomethine ylides and nitrones affords pyrrolidine-fused and isoxazolidine-fused dihydroporpholactones that display, respectively, isobacteriochlorin- and chlorin-type UV–Vis spectra ...
Ana F. R. Cerqueira +5 more
doaj +1 more source
Microwave-assisted telescoped cross metathesis-ring closing aza-Michael reaction sequence: step-economical access to nicotine–lobeline hybrid analogues† [PDF]
RSC Advances, 2015 A series of 2,5-disubstituted pyrrolidines was synthesized through an efficient telescoped cross-metathesis/cyclizing aza-Michael addition involving N-heteroaromatic olefinic derivatives.
E. Drège +4 more
doaj +1 more source
Trisubstituted 2‑Trifluoromethyl Pyrrolidines via Catalytic Asymmetric Michael Addition/Reductive Cyclization [PDF]
, 2014 : The stereoselective synthesis of trisubstituted 2-trifluoromethyl pyrrolidines by asymmetric Michael addition/hydrogenative cyclization is described.
Jeffrey S. Johnson +8 more
core +1 more source
, 2020 International audienceThe efficient approach to novel water-soluble 2-aryl-substituted N-(phosphorylmethyl)pyrrolidines via acid-catalyzed elimination/cyclization/Friedel–Crafts reaction sequence of {[(4,4-diethoxybutyl)amino]methyl}phosphonates is ...
Vagapova, Liliya +9 more
core +1 more source
Enantioselective Access to Trifluoromethylated Spirocyclopropyl Heterocycles
Advanced Science, EarlyView.We report a rhodium‐catalyzed asymmetric [2+1] spirocyclopropanation of methylene azacycles with trifluoromethyl carbenes in situ derived from fluoroalkyl triftosylhydrazones. ABSTRACT Chiral spirocyclopropyl heterocycles have emerged as privileged three‐dimensional structural motifs in medicinal chemistry.
Yuanhao Zhu +9 more
wiley +1 more source
SynOpen, 2017 A variety of sugar-fused chromanono pyrrolidines/pyrrolizidines/thiolizidines have been synthesized by intermolecular 1,3-dipolar cycloaddition reaction of azomethine ylides (generated from glucose aldehyde and different secondary amino acids) with ...
Sirisha Nallamala +2 more
doaj +1 more source
Effect of Some Synthesized Pyrrolidines in Growth of L. infantum Promastigotes
Tikrit Journal of Pure Science, 2023 In this research, three pyrrolidine compounds (P1-P3) were synthesized and then tested for efficacy against L. infantum promastigotes in vitro. The study included preparation of some chalcones and schiff bases then the condensation of both to get the
Haitham L. Al-Hayali +2 more
doaj +1 more source
Asymmetric Synthesis of Polyfunctionalized Pyrrolidines from Sulfinimine-Derived Pyrrolidine 2-Phosphonates. Synthesis of Pyrrolidine 225C [PDF]
Organic Letters, 2006 [reaction: see text] The Horner-Wadsworth-Emmons reaction of aldehydes with sulfinimine-derived 3-oxo pyrrolidine phosphonates represents a new method for the asymmetric synthesis of ring-functionalized cis-2,5-disubstituted 3-oxo pyrrolidines.
Franklin A, Davis +3 more
openaire +2 more sources
Dual Nickel/Photoredox‐Catalyzed Regio‐ and Enantioselective Alkenylation of Epoxides
Advanced Science, EarlyView.Ni/photoredox‐catalyzed stereoconvergent cross‐electrophile coupling of racemic epoxides with alkenyl bromides is described, affording β‐alkenyl products with up to 95% ee, excellent E‐selectivity, and complete regiocontrol. These versatile intermediates enable diverse chiral synthons; mechanistic studies suggest a halide ring‐opening followed by ...
Hongyan Lan +4 more
wiley +1 more source
Transient and intermediate carbocations in ruthenium tetroxide oxidation of saturated rings
Beilstein Journal of Organic Chemistry, 2019 The ruthenium tetroxide-mediated oxidation of cyclopentane, tetrahydrofuran, tetrahydrothiophene and N-substituted pyrrolidines has been studied computationally by DFT and topological (analysis of the electron localization function, ELF) methods.
Manuel Pedrón +5 more
doaj +1 more source