Results 41 to 50 of about 29,810 (265)

Synthesis of dienes from pyrrolidines using skeletal modification

Nature Communications, 2023
Saturated N-heterocyclic pyrrolidines are common in natural products, medicinal compounds and agrochemicals. However, reconstruction of their skeletal structures creating new chemical space is a challenging task, and limited methods exist for this ...
Haitao Qin, Ting Guo, Ken Lin, Guigen Li, Hongjian Lu   +4 more
doaj   +1 more source

Effect of Some Synthesized Pyrrolidines in Growth of L. infantum Promastigotes

Tikrit Journal of Pure Science, 2023
In this research, three pyrrolidine compounds (P1-P3) were synthesized and then tested for efficacy against L. infantum promastigotes in vitro. The study included preparation of some chalcones and schiff bases then the condensation of both to get the
Haitham L. Al-Hayali, Abdulwahhab J. Al-Hamadany, Muntaha M. Al-Kattan   +2 more
doaj   +1 more source

Concise Synthesis of (+)-allo-Kainic Acid via MgI2-Mediated Tandem Aziridine Ring Opening-Formal [3+2] Cycloaddition [PDF]

, 2013
3-Methyl vinyl aziridine undergoes a mild MgI2-promoted S(N)2' ring opening and concomitant cyclization with fumarate Michael acceptors to give trisubstituted pyrrolidines. The process is efficient and highly diastereoselective. This methodology has been
Aggarwal, Varinder K., Arena, Giada, Chen, Chia-Chun, Leonori, Daniele   +3 more
core   +1 more source

5-(Diphenylmethylidene)pyrrolidin-2-one [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the title compound, C(17)H(15)NO, the dihedral angle between the phenyl rings is 80.1 (2)°. In the crystal, mol-ecules are linked by pairs of N-H⋯O hydrogen bonds, forming inversion dimers.
Hsu, Tzu-Fang, Chen, Yan-Ru, Huang, Bor-Hunn, Chen, Ming-Jen   +3 more
openaire   +2 more sources

Synthesis, Functionalization, and Reactivity of Vinyl Sulfondiimidamides

Angewandte Chemie, EarlyView.
Combining unsymmetrical sulfurdiimide reagents (R‐NSN‐R1) and Grignard reagents, followed by oxidative amination, delivers a series of vinyl sulfondiimidamides. Reactivity with cysteine and lysine derivatives is shown, and the cysteine reactivity is mapped in detail. Variation of the two imidic N‐substituents can be used to tune reactivity of these new
Katherine G. Rodden, Agamemnon E. Crumpton, Samuel E. Dalton, Michael A. Clegg, Michael C. Willis   +4 more
wiley   +2 more sources

Synthesis of 1,4-imino-L-lyxitols modified at C-5 and their evaluation as inhibitors of GH38 α-mannosidases

Beilstein Journal of Organic Chemistry, 2018
A synthetic approach to 1,4-imino-L-lyxitols with various modifications at the C-5 position is reported. These imino-L-lyxitol cores were used for the preparation of a series of N-(4-halobenzyl)polyhydroxypyrrolidines.
Maroš Bella, Sergej Šesták, Ján Moncoľ, Miroslav Koóš, Monika Poláková   +4 more
doaj   +1 more source

Highly Efficient Construction of Sugar-Fused Spirochromanono Pyrrolidines/Pyrrolizidines/Thiolizidines via 1,3-Dipolar Cycloaddition of Azomethine Ylides

SynOpen, 2017
A variety of sugar-fused chromanono pyrrolidines/pyrrolizidines/thiolizidines have been synthesized by intermolecular 1,3-dipolar cycloaddition reaction of azomethine ylides (generated from glucose aldehyde and different secondary amino acids) with ...
Sirisha Nallamala, Srikumar Mannem, Raghunathan Raghavachary   +2 more
doaj   +1 more source

Synthesis of Polyhydroxylated Pyrrolidinyl Analogs of Sugar Nucleotides. Experimental and Computational Studies on Their Interactions With GalNAC-T's. [PDF]

Chembiochem
A multidisciplinary approach based on organic synthesis supported by quantum mechanical calculations, efficient phosphorylation methods, affinity studies using conventional techniques and saturation transfer difference nuclear magnetic resonance, together with molecular dynamics simulations, has enabled the preparation of nucleotide analogs with ...
Merino P, Juste V, Montesa A, Pereira S, Orta S, Pedrón M, Jiménez AI, Martín-Santamaría S, Hurtado-Guerrero R, Delso I, Tejero T.   +10 more
europepmc   +2 more sources

Synthesis of ω-Oxo Amino Acids and trans-5-Substituted Proline Derivatives using Cross-methathesis of Unsaturated Amino Acids [PDF]

, 2016
A range of 7-oxo, 8-oxo and 9-oxo amino acids, analogues of 8-oxo-2-aminodecanoic acid, one of the key components of the cyclic tetrapeptide apicidin, has been prepared by a three-step process involving copper-catalysed allylation of serine-, aspartic ...
Adams, H., Jackson, R.F., Salih, N.
core   +1 more source

Establishing a Model Precursor System: Over a Decade of Research on Carbon Dots from the Citric Acid‐Urea System

Advanced Functional Materials, EarlyView.
The citric acid/urea (CA‐Urea) precursor system offers a versatile, scalable route to carbon dots with tunable luminescence and multifunctionality. Mechanistic insights into precursor chemistry and reaction parameters have enabled doping, surface modification, and hybridization strategies, yielding CDs for luminescent devices, sensing, catalysis ...
Yupeng Liu, Zhiqi Cai, Xiangxin Sun, Hanyi Zhang, Yiming Hao, Jun Wu, Zekun Yan, Xue Wu, Yiqi Liang, Liming Wang, Songnan Qu   +10 more
wiley   +1 more source